{"doi":"10.1002/ajmg.b.32387","title":"No association between schizophrenia susceptibility variants and macroscopic structural brain volume variation in healthy subjects","abstract":"<jats:sec><jats:label /><jats:p>Previous studies have suggested that genetic variants for schizophrenia susceptibility might contribute to structural brain volume variations in schizophrenia patients, including total brain volume, hippocampal volume, and amygdalar volume. However, whether these schizophrenia susceptibility variants are associated with macroscopic structural brain volume (i.e., intracranial volume, total brain volume, and hippocampal volume) in healthy subjects is still unclear. In this study, we investigated the associations between 47 schizophrenia susceptibility variants (from 25 well‐characterized schizophrenia susceptibility genes) and cranial volume variation in a healthy Chinese sample (N = 1,013). We also extracted the association between these 47 schizophrenia risk variants and the macroscopic structural brain volume (intracranial volume, total brain volume and hippocampal volume) in a large healthy sample of European ancestry (ENIGMA sample, N = 5,775). We identified several single‐nucleotide polymorphisms (SNPs) nominally associated with intracranial volume, total brain volume, and hippocampal volume at <jats:italic>P</jats:italic> &lt; 0.05 (uncorrected). However, after Bonferroni corrections for multiple testing, no SNP showed significant association. Hence, our results do not support previous observations that schizophrenia susceptibility variants are associated with brain structure (e.g., hippocampal volume) in healthy individuals, and indicate that single schizophrenia risk variant may not contribute significantly to macroscopic brain structure (e.g., intracranial volume or hippocampal volume) variation in healthy subjects. © 2015 Wiley Periodicals, Inc.</jats:p></jats:sec>","journal":"American Journal of Medical Genetics Part B: Neuropsychiatric Genetics","year":2016,"id":606575,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1347522,"name":"Liang Huang","orcid":"0000-0003-1663-7025","position":1,"is_corresponding":false},{"id":635158,"name":"Jinkai Wang","orcid":"0000-0002-2577-7575","position":2,"is_corresponding":false},{"id":116414,"name":"Bing Su","orcid":null,"position":3,"is_corresponding":false},{"id":116405,"name":"Xiong‐Jian Luo","orcid":null,"position":4,"is_corresponding":false},{"id":897578,"name":"Ming Li","orcid":"0000-0001-6665-8559","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"No association between schizophrenia susceptibility variants and macroscopic structural brain volume variation in healthy subjects","abstract":"<jats:sec><jats:label /><jats:p>Previous studies have suggested that genetic variants for schizophrenia susceptibility might contribute to structural brain volume variations in schizophrenia patients, including total brain volume, hippocampal volume, and amygdalar volume. However, whether these schizophrenia susceptibility variants are associated with macroscopic structural brain volume (i.e., intracranial volume, total brain volume, and hippocampal volume) in healthy subjects is still unclear. In this study, we investigated the associations between 47 schizophrenia susceptibility variants (from 25 well‐characterized schizophrenia susceptibility genes) and cranial volume variation in a healthy Chinese sample (N = 1,013). We also extracted the association between these 47 schizophrenia risk variants and the macroscopic structural brain volume (intracranial volume, total brain volume and hippocampal volume) in a large healthy sample of European ancestry (ENIGMA sample, N = 5,775). We identified several single‐nucleotide polymorphisms (SNPs) nominally associated with intracranial volume, total brain volume, and hippocampal volume at <jats:italic>P</jats:italic> &lt; 0.05 (uncorrected). However, after Bonferroni corrections for multiple testing, no SNP showed significant association. Hence, our results do not support previous observations that schizophrenia susceptibility variants are associated with brain structure (e.g., hippocampal volume) in healthy individuals, and indicate that single schizophrenia risk variant may not contribute significantly to macroscopic brain structure (e.g., intracranial volume or hippocampal volume) variation in healthy subjects. © 2015 Wiley Periodicals, Inc.</jats:p></jats:sec>","is_dataset_classified":null,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26437209","pmcid":null,"openalex_id":"https://openalex.org/W1827224149","authors":[],"funders":[{"funder_name":"Thousand Talents Program (Recruitment Program of Global Youth Experts) of China","grant_id":"","title":null},{"funder_name":"100 Talents Program (BaiRenJiHua) of the Chinese Academy of Sciences","grant_id":"","title":null}],"total_grants":2,"fwci":0.476,"citation_percentile":0.71789586,"influential_citations":0,"citation_trend":[{"year":2017,"count":2},{"year":2020,"count":1},{"year":2022,"count":1}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fajmg.b.32387","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajmg.b.32387","host_type":"publisher"},{"url":"https://doi.org/10.1002/ajmg.b.32387","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26437209","host_type":"repository"}],"fields_of_study":["Genetic Associations and Epidemiology","Cardiac electrophysiology and arrhythmias","Schizophrenia research and treatment","Adult","Asian People","Brain","Female","Genetic Association Studies","Genetic Predisposition to Disease","Health","Humans","Male","Organ Size","Polymorphism, Single Nucleotide","Schizophrenia","Young Adult"],"mesh_terms":["Adult","Brain","Female","Health","Humans","Male","Organ Size","Schizophrenia","Genetic Predisposition to Disease","Polymorphism, Single Nucleotide","Asian People","Young Adult","Genetic Association Studies"],"keywords":["Brain size","Schizophrenia (object-oriented programming)","Single-nucleotide polymorphism","Hippocampal formation","Volume (thermodynamics)","Imaging genetics","Genetic predisposition","Psychosis","Neuroscience","Medicine","Neuroimaging","Psychology","Pathology","Magnetic resonance imaging","Biology","Genetics","Psychiatry","Genotype","Gene","Schizophrenia","Genetic Association","Brain Volume","Healthy Individuals"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T04:49:19.260804Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}