{"doi":"10.1002/ajim.23142","title":"Benzene exposure‐response and risk of lymphoid neoplasms in Chinese workers: A multicenter case‐cohort study","abstract":"BACKGROUND: While international agreement supports a causal relationship of benzene exposure with acute myeloid leukemia, there is debate about benzene and lymphoid neoplasm risks. METHODS: In a case-cohort study with follow-up of 110 631 Chinese workers during 1972-1999, we evaluated benzene exposure-response for non-Hodgkin lymphoma (NHL), lymphoid leukemias (LL), acute lymphocytic leukemia (ALL), and total lymphoid neoplasms (LN). We estimated benzene exposures using state-of-the-art hierarchical modeling of occupational factors calibrated with historical routine measurements and evaluated cumulative exposure-response using Cox regression. RESULTS: NHL and other specified LN were increased in exposed vs unexposed workers. However, there was no evidence of exposure-response for NHL or other specified LN. Based on a linear exposure-response, relative risks at 100 parts per million-years (RR at 100 ppm-years) for cumulative benzene exposure using a 2-year lag (exposure at least 2 years before the time at risk) were 1.05 for NHL (95 percent confidence interval (CI) = 0.97, 1.27; 32 cases), 1.11 for LL (95% CI < 0, 1.66; 12 cases), 1.21 for ALL (95% CI < 0, 3.53; 10 cases), and 1.02 for total LN (95% CI < 0, 1.16; 49 cases). No statistically significant exposure-response trends were apparent for these LN for 2 to <10-year or ≥10-year lags. NHL risks were not significantly modified by sex, age, or year at first exposure, attained age, or time since exposure. CONCLUSION: Given the study strengths and limitations, we found little evidence of exposure-response for benzene and NHL, LL, ALL, or total LN, although NHL and other specified LN were increased in exposed vs unexposed individuals.","journal":"American Journal of Industrial Medicine","year":2020,"id":83468,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8714,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":253104,"name":"Ethel S. Gilbert","orcid":null,"position":1,"is_corresponding":false},{"id":431052,"name":"Rudolf Vermeulen","orcid":null,"position":2,"is_corresponding":false},{"id":310850,"name":"Graça M. Dores","orcid":"0000-0002-3985-2935","position":3,"is_corresponding":false},{"id":431053,"name":"Songnian Yin","orcid":null,"position":4,"is_corresponding":false},{"id":406510,"name":"Lützen Portengen","orcid":"0000-0003-1537-1843","position":5,"is_corresponding":false},{"id":265961,"name":"Richard B. Hayes","orcid":"0000-0002-0918-661X","position":6,"is_corresponding":false},{"id":429731,"name":"Bu‐Tian Ji","orcid":"0000-0002-8000-4997","position":7,"is_corresponding":false},{"id":340014,"name":"Qing Lan","orcid":"0000-0002-0888-8839","position":8,"is_corresponding":false},{"id":429732,"name":"Guilan Li","orcid":"0009-0000-6801-7747","position":9,"is_corresponding":false},{"id":96418,"name":"Nathaniel Rothman","orcid":"0000-0001-6924-0895","position":10,"is_corresponding":false},{"id":251241,"name":"Martha S. Linet","orcid":"0000-0002-1687-5587","position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":null,"created_at":"2026-07-18T21:54:32.422022Z","pmid":"32474961","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}