{"doi":"10.1002/ajhb.23983","title":"Effects of exercise on whole‐blood transcriptome profile in children with overweight/obesity","abstract":"BACKGROUND: The current knowledge about the molecular mechanisms underlying the health benefits of exercise is still limited, especially in childhood. We set out to investigate the effects of a 20-week exercise intervention on whole-blood transcriptome profile (RNA-seq) in children with overweight/obesity. METHODS: Twenty-four children (10.21 ± 1.33 years, 46% girls) with overweight/obesity, were randomized to either a 20-week exercise program (intervention group; n = 10), or to a no-exercise control group (n = 14). Whole-blood transcriptome profile was analyzed using RNA-seq by STRT technique with GlobinLock technology. RESULTS: Following the 20-week exercise intervention program, 161 genes were differentially expressed between the exercise and the control groups among boys, and 121 genes among girls (p-value <0.05), while after multiple correction, no significant difference between exercise and control groups persisted in gene expression profiles (FDR >0.05). Genes enriched in GO processes and molecular pathways showed different immune response in boys (antigen processing and presentation, infections, and T cell receptor complex) and in girls (Fc epsilon RI signaling pathway) (FDR <0.05). CONCLUSION: These results suggest that 20-week exercise intervention program alters the molecular pathways involved in immune processes in children with overweight/obesity.","journal":"American Journal of Human Biology","year":2023,"id":371647,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8572,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":773765,"name":"Abel Plaza‐Florido","orcid":"0000-0002-5374-3129","position":1,"is_corresponding":false},{"id":773767,"name":"Francisco J. Esteban","orcid":"0000-0002-7135-2973","position":2,"is_corresponding":false},{"id":1131629,"name":"Augusto Anguita‐Ruiz","orcid":"0000-0001-6888-1041","position":3,"is_corresponding":false},{"id":1131630,"name":"Kaarel Krjutškov","orcid":"0000-0003-1297-1464","position":4,"is_corresponding":false},{"id":77670,"name":"Shintaro Katayama","orcid":"0000-0001-7581-5157","position":5,"is_corresponding":false},{"id":523655,"name":"Elísabet Einarsdóttir","orcid":"0000-0003-3101-2285","position":6,"is_corresponding":false},{"id":16240,"name":"Juha Kere","orcid":"0000-0003-1974-0271","position":7,"is_corresponding":false},{"id":235321,"name":"Shlomit Radom‐Aizik","orcid":"0009-0004-4023-7026","position":8,"is_corresponding":false},{"id":24249,"name":"Francisco B. Ortega","orcid":"0000-0003-2001-1121","position":9,"is_corresponding":false},{"id":773766,"name":"Signe Altmäe","orcid":"0000-0002-0708-1865","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":null,"created_at":"2026-07-19T01:15:49.453761Z","pmid":"37715654","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}