{"doi":"10.1002/ajh.2830320307","title":"Distribution of breakpoint within the breakpoint cluster region (<i>bcr</i>) in chronic myelogenous leukemia with a complex philadelphia chromosome translocation","abstract":"<jats:title>Abstract</jats:title><jats:p>We analyzed, by Southern blot hybridization, the site of breakpoint within the breakpoint cluster region (<jats:italic>bcr</jats:italic>) in six patients with a complex Philadelphia chromosome (Ph) translocation and in 23 unselected patients with a standard Ph. The breakpoint was found within the 5.8 kb <jats:italic>bcr in all 29 patients. When the bcr</jats:italic> was subdivided into four parts, fragments I–IV, based on the restriction enzyme sites, among the six patients with a complex Ph, two had a breakpoint at fragment I, three at fragment II, and one at fragment III. This distribution of breakpoints in patients with a complex Ph did not differ significantly from that in patients with a standard Ph. A deletion of an allele within the <jats:italic>bcr</jats:italic> was found in three patients (50%) with a complex Ph and in three (13%) with a standard Ph. The internal <jats:italic>bcr</jats:italic> deletion may be more common in patients with a complex Ph.</jats:p>","journal":"American Journal of Hematology","year":1989,"id":661880,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":663888,"name":"Johji Inazawa","orcid":"0000-0002-3945-2800","position":1,"is_corresponding":false},{"id":1727900,"name":"Shinichi Misawa","orcid":null,"position":2,"is_corresponding":false},{"id":1727901,"name":"Kazuhiro Nishida","orcid":null,"position":3,"is_corresponding":false},{"id":789050,"name":"Tsukasa Okuda","orcid":"0000-0003-4390-6761","position":4,"is_corresponding":false},{"id":1727902,"name":"Shigeo Horiike","orcid":null,"position":5,"is_corresponding":false},{"id":1727903,"name":"Shoichiro Tsuda","orcid":null,"position":6,"is_corresponding":false},{"id":1650936,"name":"Masafumi Taniwaki","orcid":null,"position":7,"is_corresponding":false},{"id":1727904,"name":"Tatsuo Abe","orcid":null,"position":8,"is_corresponding":false},{"id":1727897,"name":"Hikari Nishigaki","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Distribution of breakpoint within the breakpoint cluster region (<i>bcr</i>) in chronic myelogenous leukemia with a complex philadelphia chromosome translocation","abstract":"<jats:title>Abstract</jats:title><jats:p>We analyzed, by Southern blot hybridization, the site of breakpoint within the breakpoint cluster region (<jats:italic>bcr</jats:italic>) in six patients with a complex Philadelphia chromosome (Ph) translocation and in 23 unselected patients with a standard Ph. The breakpoint was found within the 5.8 kb <jats:italic>bcr in all 29 patients. When the bcr</jats:italic> was subdivided into four parts, fragments I–IV, based on the restriction enzyme sites, among the six patients with a complex Ph, two had a breakpoint at fragment I, three at fragment II, and one at fragment III. This distribution of breakpoints in patients with a complex Ph did not differ significantly from that in patients with a standard Ph. A deletion of an allele within the <jats:italic>bcr</jats:italic> was found in three patients (50%) with a complex Ph and in three (13%) with a standard Ph. The internal <jats:italic>bcr</jats:italic> deletion may be more common in patients with a complex Ph.</jats:p>","is_dataset_classified":null,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"2816913","pmcid":null,"openalex_id":"https://openalex.org/W2021277771","authors":[],"funders":[],"total_grants":0,"fwci":0.3712,"citation_percentile":0.5473331,"influential_citations":0,"citation_trend":[{"year":2012,"count":1}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fajh.2830320307","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajh.2830320307","host_type":"publisher"},{"url":"https://doi.org/10.1002/ajh.2830320307","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/2816913","host_type":"repository"}],"fields_of_study":["Chronic Myeloid Leukemia Treatments","Chronic Lymphocytic Leukemia Research","DNA and Nucleic Acid Chemistry","Alleles","Chromosome Deletion","Chronic Disease","Gene Rearrangement","Humans","Karyotyping","Leukemia, Myelogenous, Chronic, BCR-ABL Positive","Philadelphia Chromosome","Translocation, Genetic"],"mesh_terms":["Alleles","Chromosome Deletion","Chronic Disease","Humans","Karyotyping","Philadelphia Chromosome","Translocation, Genetic","Gene Rearrangement","Leukemia, Myelogenous, Chronic, BCR-ABL Positive"],"keywords":["breakpoint cluster region","Breakpoint","Chromosomal translocation","Philadelphia chromosome","Chronic myelogenous leukemia","Biology","Chromosome","Southern blot","Genetics","Molecular biology","Chromosome 22","Leukemia","DNA","Receptor","Gene"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T11:50:52.996857Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}