{"doi":"10.1002/ajh.27161","title":"Phase Ib study of sabatolimab (<scp>MBG453</scp>), a novel immunotherapy targeting <scp>TIM‐3</scp> antibody, in combination with decitabine or azacitidine in high‐ or very high‐risk myelodysplastic syndromes","abstract":"The safety and efficacy of sabatolimab, a novel immunotherapy targeting T-cell immunoglobulin domain and mucin domain-3 (TIM-3), was assessed in combination with hypomethylating agents (HMAs) in patients with HMA-naive revised International Prognostic System Score (IPSS-R) high- or very high-risk myelodysplastic syndromes (HR/vHR-MDS) or chronic myelomonocytic leukemia (CMML). Sabatolimab + HMA had a safety profile similar to that reported for HMA alone and demonstrated durable clinical responses in patients with HR/vHR-MDS. 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