{"doi":"10.1002/ajh.26908","title":"High response rates and transition to transplant after novel targeted and cellular therapies in adults with relapsed/refractory acute lymphoblastic leukemia with <scp>Philadelphia‐like</scp> fusions","abstract":"Philadelphia (Ph)-like acute lymphoblastic leukemia (ALL) is associated with a poor response to standard chemotherapy. However, outcomes with novel antibody and cellular therapies in relapsed/refractory (r/r) Ph-like ALL are largely unknown. We conducted a single-center retrospective analysis of adult patients (n = 96) with r/r B-ALL and fusions associated with Ph-like who received novel salvage therapies. Patients were treated with 149 individual novel regimens (blinatumomab = 83, inotuzumab ozogamicin [InO] = 36, and CD19CAR T cells = 30). The median age at first novel salvage therapy was 36 years (range; 18-71). Ph-like fusions were IGH::CRLF2 (n = 48), P2RY8::CRLF2 (n = 26), JAK2 (n = 9), ABL-class (n = 8), EPOR::IGH (n = 4) and ETV6::NTRK2 (n = 1). CD19CAR T cells were administered later in the course of therapy compared to blinatumomab and InO (p < .001) and more frequently in recipients who relapsed after allogeneic hematopoietic cell transplantation (alloHCT) (p = .002). Blinatumomab was administered at an older age compared to InO and CAR T-cells (p = .004). The complete remission (CR)/CR with incomplete hematologic recovery (CRi) rates were 63%, 72%, and 90% following blinatumomab, InO and CD19CAR, respectively, among which 50%, 50%, and 44% of responders underwent consolidation with alloHCT, respectively. In multivariable analysis, the type of novel therapy (p = .044) and pretreatment marrow blasts (p = .006) predicted the CR/CRi rate, while the Ph-like fusion subtype (p = .016), pretreatment marrow blasts (p = .022) and post-response consolidation with alloHCT (p < .001) influenced event-free survival. In conclusion, novel therapies are effective in inducing high remission rates in patients with r/r Ph-like ALL and successfully transitioning the responders to alloHCT.","journal":"American Journal of Hematology","year":2023,"id":356920,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9175,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":780091,"name":"Michelle Afkhami","orcid":"0000-0001-5830-6158","position":1,"is_corresponding":false},{"id":318404,"name":"Dongyun Yang","orcid":"0000-0003-0736-4977","position":2,"is_corresponding":false},{"id":253485,"name":"Zhaohui Gu","orcid":"0000-0003-1581-1327","position":3,"is_corresponding":false},{"id":319462,"name":"Sally Mokhtari","orcid":null,"position":4,"is_corresponding":false},{"id":487745,"name":"Shilpa Shahani","orcid":null,"position":5,"is_corresponding":false},{"id":955034,"name":"Hoda Pourhassan","orcid":"0000-0003-3862-4612","position":6,"is_corresponding":false},{"id":284126,"name":"Vaibhav Agrawal","orcid":"0000-0002-6383-3777","position":7,"is_corresponding":false},{"id":432776,"name":"Paul Koller","orcid":"0000-0003-3830-5320","position":8,"is_corresponding":false},{"id":432775,"name":"Shukaib Arslan","orcid":"0000-0002-8447-9607","position":9,"is_corresponding":false},{"id":1106439,"name":"Vanina Tomasian","orcid":null,"position":10,"is_corresponding":false},{"id":318403,"name":"Monzr M. 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