{"doi":"10.1002/ajh.26834","title":"Association of <scp>ABO</scp> mismatch with the outcomes of allogeneic hematopoietic cell transplantation for acute leukemia","abstract":"Allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative treatment for acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). While many factors influence the outcomes of allo-HCT, the independent impact of donor-recipient ABO mismatching remains unclear. Using the Center for International Blood and Marrow Transplant Research (CIBMTR) database, we identified patients aged ≥18 years with AML or ALL who underwent allo-HCT between 2008 and 2018. Our objectives were to analyze the outcomes of allo-HCT based on the donor-recipient ABO status (match, minor mismatch, major mismatch, bidirectional mismatch). Among 4946 eligible patients, 2741 patients (55.4%) were ABO matched, 1030 patients (20.8%) had a minor ABO mismatch, 899 patients (18.1%) had a major ABO mismatch, and 276 patients (5.6%) had a bidirectional ABO mismatch. In multivariable analyses, compared to ABO matched allo-HCT, the presence of a major ABO mismatch was associated with worse overall survival (HR 1.16, 95% CI 1.05-1.29; p = 0.005), inferior platelet engraftment (HR 0.83, 95% CI 0.77-0.90; p < 0.001), and higher primary graft failure (HR 1.60, 95% CI 1.12-2.30, p = 0.01). Relapse, acute graft versus host disease (GVHD) grades III-IV and chronic GVHD were not significantly associated with ABO status. While donor age was not significantly associated with outcomes, older recipient age was associated with worse survival and non-relapse mortality. Our study demonstrates that donor-recipient ABO status is independently associated with survival and other post-transplantation outcomes in acute leukemia. This underscores the importance of considering the ABO status in donor selection algorithms and its impact in acute leukemia.","journal":"American Journal of Hematology","year":2023,"id":332519,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":24,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9617,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":244899,"name":"Brent R. Logan","orcid":"0000-0002-4473-4044","position":1,"is_corresponding":false},{"id":349700,"name":"Stephanie Bo‐Subait","orcid":null,"position":2,"is_corresponding":false},{"id":284131,"name":"Amer Beitinjaneh","orcid":"0000-0002-1661-5865","position":3,"is_corresponding":false},{"id":122963,"name":"Steven M. Devine","orcid":"0000-0001-7731-759X","position":4,"is_corresponding":false},{"id":313716,"name":"Nosha Farhadfar","orcid":"0000-0002-2752-9604","position":5,"is_corresponding":false},{"id":619547,"name":"Lohith Gowda","orcid":null,"position":6,"is_corresponding":false},{"id":284138,"name":"Shahrukh K. Hashmi","orcid":"0000-0002-8914-7927","position":7,"is_corresponding":false},{"id":284140,"name":"Hillard M. Lazarus","orcid":"0000-0002-1159-5607","position":8,"is_corresponding":false},{"id":284144,"name":"Sunita Nathan","orcid":"0000-0001-7920-4265","position":9,"is_corresponding":false},{"id":313730,"name":"Akshay Sharma","orcid":"0000-0003-3281-2081","position":10,"is_corresponding":false},{"id":284153,"name":"Jean A. Yared","orcid":"0000-0002-5346-6299","position":11,"is_corresponding":false},{"id":548428,"name":"Heather E. Stefanski","orcid":"0000-0001-7527-9315","position":12,"is_corresponding":false},{"id":263463,"name":"Michael A. Pulsipher","orcid":"0000-0003-3030-8420","position":13,"is_corresponding":false},{"id":505698,"name":"Jack W. Hsu","orcid":null,"position":14,"is_corresponding":false},{"id":377134,"name":"Galen E. Switzer","orcid":"0000-0001-8541-9449","position":15,"is_corresponding":false},{"id":314286,"name":"Sandhya R. Panch","orcid":"0000-0002-7814-9150","position":16,"is_corresponding":false},{"id":122973,"name":"Bronwen E. 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