{"doi":"10.1002/ajh.26596","title":"Trajectories of quality of life recovery and symptom burden after autologous hematopoietic cell transplantation in multiple myeloma","abstract":"Early autologous hematopoietic cell transplantation (AHCT) with post-transplant maintenance therapy is standard of care in multiple myeloma (MM). While short-term quality of life (QOL) deterioration after AHCT is known, the long-term trajectories and symptom burden after transplantation are largely unknown. Toward this goal, a secondary analysis of QOL data of the BMT CTN 0702, a randomized controlled trial comparing outcomes of three treatment interventions after a single AHCT (N = 758), was conducted. FACT-BMT scores up to 4 years post-AHCT were analyzed. Symptom burden was studied using responses to 17 individual symptoms dichotomized as 'none/mild' for scores 0-2 and 'moderate/severe' for scores of 3 or 4. Patients with no moderate/severe symptom ratings were considered to have low symptom burden at 1-year. Mean age at enrollment was 55.5 years with 17% African Americans. Median follow-up was 6 years (range, 0.4-8.5 years). FACT-BMT scores improved between enrollment and 1-year and remained stable thereafter. Low symptom burden was reported by 27% of patients at baseline, 38% at 1-year, and 32% at 4 years post-AHCT. Predictors of low symptom burden at 1-year included low symptom burden at baseline: OR 2.7 (1.8-4.1), p < 0.0001; older age: OR 2.1 (1.3-3.2), p = 0.0007; and was related to being employed: OR 2.1 (1.4-3.2), p = 0.0004). We conclude that MM survivors who achieve disease control after AHCT have excellent recovery of FACT-BMT and subscale scores to population norms by 1-year post-transplant, though many patients continue to report moderate to severe severity in some symptoms at 1-year and beyond.","journal":"American Journal of Hematology","year":2022,"id":244205,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8535,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":265308,"name":"Ruta Brazauskas","orcid":null,"position":1,"is_corresponding":false},{"id":459220,"name":"Edward A. Stadtmauer","orcid":"0000-0002-3935-6069","position":2,"is_corresponding":false},{"id":122967,"name":"Marcelo C. Pasquini","orcid":"0000-0003-1579-2293","position":3,"is_corresponding":false},{"id":122966,"name":"Parameswaran Hari","orcid":"0000-0002-8800-297X","position":4,"is_corresponding":false},{"id":283681,"name":"Asad Bashey","orcid":null,"position":5,"is_corresponding":false},{"id":268267,"name":"Natalie S. Callander","orcid":"0000-0002-6975-1086","position":6,"is_corresponding":false},{"id":122963,"name":"Steven M. Devine","orcid":"0000-0001-7731-759X","position":7,"is_corresponding":false},{"id":550340,"name":"Yvonne A. Efebera","orcid":"0000-0002-4163-8823","position":8,"is_corresponding":false},{"id":284136,"name":"Siddhartha Ganguly","orcid":"0000-0003-4920-762X","position":9,"is_corresponding":false},{"id":229110,"name":"Cristina Gasparetto","orcid":"0000-0003-1513-5605","position":10,"is_corresponding":false},{"id":228974,"name":"Nancy L. Geller","orcid":"0000-0003-0500-7386","position":11,"is_corresponding":false},{"id":122977,"name":"Mary M. Horowitz","orcid":"0000-0002-9502-785X","position":12,"is_corresponding":false},{"id":551275,"name":"John Koreth","orcid":null,"position":13,"is_corresponding":false},{"id":298161,"name":"Heather Landau","orcid":"0000-0002-3152-1189","position":14,"is_corresponding":false},{"id":244908,"name":"Claudio G. Brunstein","orcid":"0000-0002-1997-3799","position":15,"is_corresponding":false},{"id":406219,"name":"Philip L. McCarthy","orcid":"0000-0002-9577-3879","position":16,"is_corresponding":false},{"id":407651,"name":"Muzaffar H. Qazilbash","orcid":"0000-0003-2876-2886","position":17,"is_corresponding":false},{"id":108874,"name":"Sergio Giralt","orcid":"0000-0003-1944-5053","position":18,"is_corresponding":false},{"id":25426,"name":"Amrita Krishnan","orcid":null,"position":19,"is_corresponding":false},{"id":369030,"name":"Kathryn E. 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