{"doi":"10.1002/advs.202518238","title":"Multi‐Tissue Genetic Regulation of RNA Editing in Pigs","abstract":"RNA editing introduces transcriptomic variation and may contribute to complex trait regulation. However, its genetic determination in pigs remains unclear. Here, using 5457 PigGTEx RNA-seq samples across 34 porcine tissues, we construct a comprehensive RNA editome and map 49 614 cis-editing quantitative trait loci (edQTLs). These edQTLs define a distinct regulatory layer, with over 32% acting independently of expression or splicing QTLs (eQTLs/sQTLs). Crucially, edQTLs are significantly enriched in GWAS loci for 33 complex traits and show a superior contribution to heritability over eQTLs/sQTLs in some traits like growth and reproduction. Colocalization analyses pinpoint diverse causal mechanisms, revealing both edQTL-specific effects (e.g., ERCC5) and coordinated events where single variants pleiotropically modulate RNA editing, splicing, and gene expression. Human-pig comparative analysis identifies hundreds of evolutionarily conserved editing events linked to fundamental neurological pathways. This study provides the first comprehensive multi-tissue porcine RNA editome and edQTL map, establishing RNA editing as a key mechanism linking genetic variation to phenotypic diversity in a major agricultural species and offering a valuable resource for future functional genomics research.","journal":"Advanced Science","year":2026,"id":2675,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0942,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2026-01-18","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":31081,"name":"Wentao Gong","orcid":null,"position":1,"is_corresponding":false},{"id":31082,"name":"Xiaodian Cai","orcid":null,"position":2,"is_corresponding":false},{"id":31083,"name":"Jinyan Teng","orcid":null,"position":3,"is_corresponding":false},{"id":31084,"name":"Jiali Cai","orcid":null,"position":4,"is_corresponding":false},{"id":31085,"name":"Haonan Zeng","orcid":null,"position":5,"is_corresponding":false},{"id":31086,"name":"Wondossen Ayalew","orcid":null,"position":6,"is_corresponding":false},{"id":31087,"name":"Qingpeng Shen","orcid":null,"position":7,"is_corresponding":false},{"id":31088,"name":"Zhanming Zhong","orcid":"0000-0002-5312-5400","position":8,"is_corresponding":false},{"id":24031,"name":"Yifei Wang","orcid":"0000-0002-3313-0974","position":9,"is_corresponding":false},{"id":31089,"name":"Wenjing Zhang","orcid":null,"position":10,"is_corresponding":false},{"id":31090,"name":"Yuhan Tian","orcid":null,"position":11,"is_corresponding":false},{"id":31091,"name":"Dantong Xu","orcid":null,"position":12,"is_corresponding":false},{"id":31092,"name":"Yahui Gao","orcid":null,"position":13,"is_corresponding":false},{"id":31093,"name":"Hongwei Yin","orcid":"0000-0003-1766-4287","position":14,"is_corresponding":false},{"id":31094,"name":"Yuebo Zhang","orcid":null,"position":15,"is_corresponding":false},{"id":31095,"name":"Jiahui Hou","orcid":null,"position":16,"is_corresponding":false},{"id":31096,"name":"Tianru Zhou","orcid":null,"position":17,"is_corresponding":false},{"id":18070,"name":"Jiaqi Li","orcid":"0000-0003-1587-5910","position":18,"is_corresponding":false},{"id":31097,"name":"Lingzhao Fang","orcid":"0000-0003-1103-3679","position":19,"is_corresponding":false},{"id":31098,"name":"Xiaolong Yuan","orcid":null,"position":20,"is_corresponding":false},{"id":20642,"name":"Zhe Zhang","orcid":"0000-0002-6791-9009","position":21,"is_corresponding":false},{"id":31080,"name":"Xiangchun Pan","orcid":null,"position":0,"is_corresponding":true}],"reference_count":75,"raw_metadata":null,"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}