{"doi":"10.1002/advs.202514862","title":"The High‐Altitude Adaptation Characteristics of Microbiota‐Host Cross‐Talk in Yak Gastrointestinal Track","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>\n                    The yak, an ideal model for studying high‐altitude hypoxia adaptation, possesses unique gastrointestinal tract (GIT) adaptability. However, understanding of cellular‐level mechanisms underlying host‐metabolite‐microbe within GIT that are crucial for growth in extreme environments remains significantly limited. Therefore, this study constructs the first comprehensive multi‐tissue cellular atlas of the yak GIT, encompassing 54 distinct cell types. Cross‐species and cross‐tissue comparative analyses combined with large‐scale population genetic data identify\n                    <jats:italic>HNF4A</jats:italic>\n                    and\n                    <jats:italic>SREBF2</jats:italic>\n                    as GIT‐specific transcription factors targeting the key gene\n                    <jats:italic>MYO6</jats:italic>\n                    , revealing unique transcriptional patterns and the significant influence of epithelial cells on yak body weight in GIT. Alongside the characterization of microorganisms and metabolites along the GIT, the important microorganism\n                    <jats:italic>Bacillus</jats:italic>\n                    infection has cell‐type specificity, and affects the accumulation of key products such as Succinate and lactic acid through the interaction between different epithelial cell metabolic activities and microorganisms and the communication between different cell types (key receptors\n                    <jats:italic>SLC27A5</jats:italic>\n                    ,\n                    <jats:italic>PPARA</jats:italic>\n                    ), thereby affecting glycolysis and TCA cycle and other processes to strengthen the adaptability of yak GIT in extreme environments. This work provides novel insights into the unique gastrointestinal adaptations of yaks to extreme environments and holds significant implications for understanding precision breeding in yaks and mammal gastrointestinal responses to hypoxia.\n                  </jats:p>","journal":"Advanced Science","year":2026,"id":625323,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":619328,"name":"Minghao Zhang","orcid":"0000-0002-3366-0465","position":1,"is_corresponding":false},{"id":1617012,"name":"Qingbo Zheng","orcid":null,"position":2,"is_corresponding":false},{"id":1617013,"name":"Qinran Yu","orcid":null,"position":3,"is_corresponding":false},{"id":1617015,"name":"Guowu Yang","orcid":null,"position":4,"is_corresponding":false},{"id":563771,"name":"Wenwen Ren","orcid":"0009-0007-2865-8874","position":5,"is_corresponding":false},{"id":407119,"name":"Xiaoming Ma","orcid":"0000-0003-1358-428X","position":6,"is_corresponding":false},{"id":1617017,"name":"Yongfu La","orcid":null,"position":7,"is_corresponding":false},{"id":1617019,"name":"Pengjia Bao","orcid":null,"position":8,"is_corresponding":false},{"id":1018654,"name":"Min Chu","orcid":"0000-0001-7572-6162","position":9,"is_corresponding":false},{"id":1617020,"name":"Xian Guo","orcid":null,"position":10,"is_corresponding":false},{"id":1617021,"name":"Chunnian Liang","orcid":null,"position":11,"is_corresponding":false},{"id":97041,"name":"Ping Yan","orcid":"0000-0002-4354-6236","position":12,"is_corresponding":false},{"id":355925,"name":"Chun Huang","orcid":"0000-0003-1358-3121","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The High‐Altitude Adaptation Characteristics of Microbiota‐Host Cross‐Talk in Yak Gastrointestinal Track","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>\n                    The yak, an ideal model for studying high‐altitude hypoxia adaptation, possesses unique gastrointestinal tract (GIT) adaptability. However, understanding of cellular‐level mechanisms underlying host‐metabolite‐microbe within GIT that are crucial for growth in extreme environments remains significantly limited. Therefore, this study constructs the first comprehensive multi‐tissue cellular atlas of the yak GIT, encompassing 54 distinct cell types. Cross‐species and cross‐tissue comparative analyses combined with large‐scale population genetic data identify\n                    <jats:italic>HNF4A</jats:italic>\n                    and\n                    <jats:italic>SREBF2</jats:italic>\n                    as GIT‐specific transcription factors targeting the key gene\n                    <jats:italic>MYO6</jats:italic>\n                    , revealing unique transcriptional patterns and the significant influence of epithelial cells on yak body weight in GIT. Alongside the characterization of microorganisms and metabolites along the GIT, the important microorganism\n                    <jats:italic>Bacillus</jats:italic>\n                    infection has cell‐type specificity, and affects the accumulation of key products such as Succinate and lactic acid through the interaction between different epithelial cell metabolic activities and microorganisms and the communication between different cell types (key receptors\n                    <jats:italic>SLC27A5</jats:italic>\n                    ,\n                    <jats:italic>PPARA</jats:italic>\n                    ), thereby affecting glycolysis and TCA cycle and other processes to strengthen the adaptability of yak GIT in extreme environments. This work provides novel insights into the unique gastrointestinal adaptations of yaks to extreme environments and holds significant implications for understanding precision breeding in yaks and mammal gastrointestinal responses to hypoxia.\n                  </jats:p>","is_dataset_classified":null,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"41144742","pmcid":"PMC12767066","openalex_id":"https://openalex.org/W4415618995","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"U23A201272","title":null},{"funder_name":"Agricultural Science and Technology Innovation Program","grant_id":"25‐LZIHPS‐01","title":null},{"funder_name":"Agricultural Science and Technology Innovation Program","grant_id":"25-LZIHPS-01","title":null},{"funder_name":"Tingzhou talent research Program","grant_id":"TZYC-TP2023","title":null},{"funder_name":"Xinjiang Tianchi talent research Program","grant_id":"TCYC-TP2023","title":null},{"funder_name":"MATS-Beef Cattle System","grant_id":"CARS-37","title":null},{"funder_name":"Central Government Guided Local Science and Technology Development Fund Projects","grant_id":"25ZYJA008","title":null},{"funder_name":"Modern beef yak industry technology system","grant_id":"","title":null},{"funder_name":"Modern beef yak industry technology system","grant_id":"","title":null}],"total_grants":9,"fwci":5.6308,"citation_percentile":0.96369728,"influential_citations":0,"citation_trend":[{"year":2025,"count":1},{"year":2026,"count":5}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/advs.202514862","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/advs.202514862","host_type":"publisher"},{"url":"https://advanced.onlinelibrary.wiley.com/doi/pdf/10.1002/advs.202514862","host_type":"publisher"},{"url":"https://advanced.onlinelibrary.wiley.com/doi/full-xml/10.1002/advs.202514862","host_type":"publisher"},{"url":"https://doi.org/10.1002/advs.202514862","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/41144742","host_type":"repository"},{"url":"https://doaj.org/article/368a05900ea24c80a1dfc1f36bdb720e","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12767066/","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC12767066","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC12767066?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["High Altitude and Hypoxia","Gut microbiota and health","Neuroscience of respiration and sleep","Animals","Cattle","Altitude","Gastrointestinal Microbiome","Gastrointestinal Tract","Adaptation, Physiological","Acclimatization"],"mesh_terms":["Acclimatization","Gastrointestinal Microbiome","Adaptation, Physiological","Altitude","Animals","Cattle","Gastrointestinal Tract"],"keywords":["YAK","Gastrointestinal tract","Adaptability","Adaptation (eye)","Population","Cell","Microorganism","Hypoxia","Cross‐species Analysis","Multi‐tissue Single‐cell Transcriptomic Atlas","Yak Gastrointestinal Tract","Microbiota‐host Crosstalk"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T06:26:40.961936Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}