{"doi":"10.1002/advs.202411181","title":"Gut Commensal <i>Barnesiella Intestinihominis</i> Ameliorates Hyperglycemia and Liver Metabolic Disorders","abstract":"Recent studies have highlighted the role of the gut microbiota in type 2 diabetes (T2D). Improving gut microbiota dysbiosis can be a potential strategy for the prevention and management of T2D. Here, this work finds that the abundance of Barnesiella intestinihominis is significantly decreased in the fecal of T2D patients from 2-independent centers. Oral treatment of live B. intestinihominis (LBI) considerably ameliorates hyperglycemia and liver metabolic disorders in HFD/STZ-induced T2D models and db/db mice. LBI-derived acetate has similar protective effects against T2D. Mechanistically, acetate enhances fibroblast growth factor 21 (FGF21) through inhibition of histone deacetylase 9 (HDAC9) to increase H3K27 acetylation at the FGF21 promoter. The screening puerarin from Gegen Qinlian decoction in a gut microbiota-dependent manner improved hyperglycemia and liver metabolic disorders by promoting the growth of B. intestinihominis. This study suggests that gut commensal B. intestinihominis and puerarin, respectively have the potential as a probiotic and prebiotic in the treatment of T2D.","journal":"Advanced Science","year":2024,"id":54,"datarank":0.8317642411208488,"base_score":3.6375861597263857,"endowment":3.6375861597263857,"self_citation_contribution":0.5456379239589579,"citation_network_contribution":0.28612631716189085,"self_endowment_contribution":0.5456379239589579,"citer_contribution":0.28612631716189085,"corpus_percentile":null,"corpus_rank":null,"citation_count":37,"citer_count":36,"citers_with_citation_signal":19,"citers_with_endowment":19,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0447,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-12-31","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":341,"name":"Dong Xu","orcid":"0000-0002-5202-4309","position":1,"is_corresponding":false},{"id":342,"name":"Xuyi Cai","orcid":null,"position":2,"is_corresponding":false},{"id":343,"name":"Xue Xing","orcid":"0000-0003-4492-7206","position":3,"is_corresponding":false},{"id":344,"name":"Xin Shao","orcid":null,"position":4,"is_corresponding":false},{"id":345,"name":"Ailing Yin","orcid":null,"position":5,"is_corresponding":false},{"id":346,"name":"Yanyan Zhao","orcid":"0000-0003-4978-1410","position":6,"is_corresponding":false},{"id":347,"name":"Mengyuan Wang","orcid":"0000-0002-4036-0751","position":7,"is_corresponding":false},{"id":348,"name":"Yu‐nuo Fan","orcid":null,"position":8,"is_corresponding":false},{"id":349,"name":"Boao Liu","orcid":null,"position":9,"is_corresponding":false},{"id":350,"name":"Hua Yang","orcid":"0000-0002-4876-4072","position":10,"is_corresponding":false},{"id":351,"name":"Wei Zhou","orcid":"0000-0001-7534-3065","position":11,"is_corresponding":false},{"id":352,"name":"Ping Li","orcid":"0000-0003-4150-3758","position":12,"is_corresponding":false},{"id":353,"name":"Xueyang Cai","orcid":"0000-0002-2132-3242","position":13,"is_corresponding":false},{"id":354,"name":"Yuqi Fan","orcid":"0000-0002-0084-2895","position":14,"is_corresponding":false},{"id":355,"name":"Bufan Liu","orcid":null,"position":15,"is_corresponding":false},{"id":340,"name":"Ye Zhang","orcid":"0009-0000-4883-8097","position":0,"is_corresponding":true}],"reference_count":61,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}