{"doi":"10.1002/advs.202308617","title":"CD38‐Specific Gallium‐68 Labeled Peptide Radiotracer Enables Pharmacodynamic Monitoring in Multiple Myeloma with PET","abstract":"Abstract The limited availability of molecularly targeted low‐molecular‐weight imaging agents for monitoring multiple myeloma (MM)‐targeted therapies has been a significant challenge in the field. In response, a first‐in‐class peptide‐based radiotracer, [ 68 Ga]Ga‐AJ206, is developed that can be seamlessly integrated into the standard clinical workflow and is specifically designed to noninvasively quantify CD38 levels and pharmacodynamics by positron emission tomography (PET). A bicyclic peptide, AJ206, is synthesized and exhibits high affinity to CD38 ( K D : 19.1 ± 0.99 × 10 −9 m ) by surface plasmon resonance. Further, [ 68 Ga]Ga‐AJ206‐PET shows high contrast within 60 min and suitable absorbed dose estimates for clinical use. Additionally, [ 68 Ga]Ga‐AJ206 detects CD38 expression in cell line‐derived xenografts, patient‐derived xenografts (PDXs), and disseminated disease models in a manner consistent with flow cytometry and immunohistochemistry findings. Moreover, [ 68 Ga]Ga‐AJ206‐PET successfully quantifies CD38 pharmacodynamics in PDXs, revealing increased CD38 expression in the tumor following all‐trans retinoic acid (ATRA) therapy. In conclusion, [ 68 Ga]Ga‐AJ206 exhibits the salient features required for clinical translation, providing CD38‐specific high‐contrast images in multiple models of MM. [ 68 Ga]Ga‐AJ206‐PET could be useful for quantifying total CD38 levels and pharmacodynamics during therapy to evaluate approved and new therapies in MM and other diseases with CD38 involvement.","journal":"Advanced Science","year":2024,"id":425893,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9455,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":890377,"name":"Kuldeep Gupta","orcid":"0000-0002-0131-0495","position":1,"is_corresponding":false},{"id":890375,"name":"Akhilesh Mishra","orcid":"0000-0002-0990-2540","position":2,"is_corresponding":false},{"id":868472,"name":"Gabriela Lofland","orcid":"0000-0003-4465-3997","position":3,"is_corresponding":false},{"id":621690,"name":"Ian R. Marsh","orcid":"0000-0002-0031-9746","position":4,"is_corresponding":false},{"id":890376,"name":"Dhiraj Kumar","orcid":"0000-0002-9414-4536","position":5,"is_corresponding":false},{"id":267503,"name":"Gabriel Ghiaur","orcid":"0000-0002-3955-7944","position":6,"is_corresponding":false},{"id":259089,"name":"Philip Imus","orcid":"0000-0001-8563-195X","position":7,"is_corresponding":false},{"id":267038,"name":"Steven P. Rowe","orcid":"0000-0003-2897-4694","position":8,"is_corresponding":false},{"id":338671,"name":"Robert F. Hobbs","orcid":"0000-0002-1328-7114","position":9,"is_corresponding":false},{"id":430280,"name":"Christian B. Gocke","orcid":"0000-0001-8013-9886","position":10,"is_corresponding":false},{"id":310943,"name":"Sridhar Nimmagadda","orcid":"0000-0002-6413-7191","position":11,"is_corresponding":false},{"id":890378,"name":"Ajay Sharma","orcid":"0000-0003-1361-6923","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-19T01:58:32.160975Z","pmid":"38421139","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}