{"doi":"10.1002/advs.202307937","title":"Tryptophan As a New Member of RNA‐Induced Silencing Complexes Prevents Colon Cancer Liver Metastasis","abstract":"Essential amino acids (EAA) and microRNAs (miRs) control biological activity of a cell. Whether EAA regulates the activity of miR has never been demonstrated. Here, as proof-of-concept, a tryptophan (Trp, an EAA) complex containing Argonaute 2 (Ago2) and miRs including miR-193a (Trp/Ago2/miR-193a) is identified. Trp binds miR-193a-3p and interacts with Ago2. Trp/Ago2/miR-193a increases miR-193a-3p activity via enhancing Argonaute 2 (Ago2) RNase activity. Other miRs including miR-103 and miR-107 in the Trp complex enhance miR-193a activity by targeting the same genes. Mechanistically, the Trp/Ago2/miR-193a complex interacts with Trp-binding pockets of the PIWI domain of Ago2 to enhance Ago2 mediated miR activity. This newly formed Ago2/Trp/miR-193a-3p complex is more efficient than miR-193a-3p alone in inhibiting the expression of targeted genes and inhibiting colon cancer liver metastasis. The findings show that Trp regulates miR activity through communication with the RNA-induced silencing complexes (RISC), which provides the basis for tryptophan based miR therapy.","journal":"Advanced Science","year":2024,"id":456064,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9545,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":629674,"name":"Yi Ren","orcid":"0000-0002-0176-493X","position":1,"is_corresponding":false},{"id":295147,"name":"Yun Teng","orcid":"0000-0003-2365-1626","position":2,"is_corresponding":false},{"id":296756,"name":"Jingyao Mu","orcid":null,"position":3,"is_corresponding":false},{"id":1280515,"name":"Jie Tang","orcid":"0000-0002-6219-8177","position":4,"is_corresponding":false},{"id":296757,"name":"Kumaran Sundaram","orcid":null,"position":5,"is_corresponding":false},{"id":620404,"name":"Lifeng Zhang","orcid":"0000-0003-3811-5615","position":6,"is_corresponding":false},{"id":284080,"name":"Juw Won Park","orcid":"0000-0002-4610-6893","position":7,"is_corresponding":false},{"id":323474,"name":"Jae Yeon Hwang","orcid":"0000-0002-6493-4182","position":8,"is_corresponding":false},{"id":250194,"name":"Jun Yan","orcid":"0000-0003-2922-422X","position":9,"is_corresponding":false},{"id":250786,"name":"Gerald W. Dryden","orcid":"0000-0001-9787-4537","position":10,"is_corresponding":false},{"id":295156,"name":"Huang‐Ge Zhang","orcid":"0000-0001-9665-9202","position":11,"is_corresponding":false},{"id":295148,"name":"Fangyi Xu","orcid":"0000-0002-6764-8616","position":0,"is_corresponding":true}],"reference_count":78,"raw_metadata":null,"created_at":"2026-07-19T02:03:27.785212Z","pmid":"39031551","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}