{"doi":"10.1002/advs.202302483","title":"Real‐Time Monitoring of Multitarget Antimicrobial Mechanisms of Peptoids Using Label‐Free Imaging with Optical Diffraction Tomography","abstract":"Antimicrobial peptides (AMPs) are promising therapeutics in the fight against multidrug-resistant bacteria. As a mimic of AMPs, peptoids with N-substituted glycine backbone have been utilized for antimicrobials with resistance against proteolytic degradation. Antimicrobial peptoids are known to kill bacteria by membrane disruption; however, the nonspecific aggregation of intracellular contents is also suggested as an important bactericidal mechanism. Here,structure-activity relationship (SAR) of a library of indole side chain-containing peptoids resulting in peptoid 29 as a hit compound is investigated. Then, quantitative morphological analyses of live bacteria treated with AMPs and peptoid 29 in a label-free manner using optical diffraction tomography (ODT) are performed. It is unambiguously demonstrated that both membrane disruption and intracellular biomass flocculation are primary mechanisms of bacterial killing by monitoring real-time morphological changes of bacteria. These multitarget mechanisms and rapid action can be a merit for the discovery of a resistance-breaking novel antibiotic drug.","journal":"Advanced Science","year":2023,"id":332816,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":24,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9529,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1059467,"name":"Yeongmi Cheon","orcid":"0000-0001-8986-9308","position":1,"is_corresponding":false},{"id":1059468,"name":"Dongmin Shin","orcid":"0000-0002-5562-0771","position":2,"is_corresponding":false},{"id":1059469,"name":"Jieun Choi","orcid":"0000-0002-1989-2091","position":3,"is_corresponding":false},{"id":850802,"name":"Josefine Eilsø Nielsen","orcid":"0000-0001-9274-5533","position":4,"is_corresponding":false},{"id":1010000,"name":"Myeong Seon Jeong","orcid":"0000-0002-4116-3397","position":5,"is_corresponding":false},{"id":1059470,"name":"Ho Yeon Nam","orcid":"0000-0002-1077-7206","position":6,"is_corresponding":false},{"id":1059995,"name":"Sung‐Hak Kim","orcid":null,"position":7,"is_corresponding":false},{"id":850805,"name":"Reidar Lund","orcid":"0000-0001-8017-6396","position":8,"is_corresponding":false},{"id":525619,"name":"Håvard Jenssen","orcid":"0000-0003-0007-0335","position":9,"is_corresponding":false},{"id":525620,"name":"Annelise E. Barron","orcid":"0000-0002-0735-6873","position":10,"is_corresponding":false},{"id":1059471,"name":"Seongsoo Lee","orcid":"0000-0002-8012-9749","position":11,"is_corresponding":false},{"id":633961,"name":"Jiwon Seo","orcid":"0000-0002-5433-5071","position":12,"is_corresponding":false},{"id":1059466,"name":"Minsang Kim","orcid":"0009-0003-1745-8608","position":0,"is_corresponding":true}],"reference_count":75,"raw_metadata":null,"created_at":"2026-07-19T01:09:35.125543Z","pmid":"37341246","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}