{"doi":"10.1002/advs.202204190","title":"PPARγ Acetylation Orchestrates Adipose Plasticity and Metabolic Rhythms","abstract":"Systemic glucose metabolism and insulin activity oscillate in response to diurnal rhythms and nutrient availability with the necessary involvement of adipose tissue to maintain metabolic homeostasis. However, the adipose-intrinsic regulatory mechanism remains elusive. Here, the dynamics of PPARγ acetylation in adipose tissue are shown to orchestrate metabolic oscillation in daily rhythms. Acetylation of PPARγ displays a diurnal rhythm in young healthy mice, with the peak at zeitgeber time 0 (ZT0) and the trough at ZT18. This rhythmic pattern is deranged in pathological conditions such as obesity, aging, and circadian disruption. The adipocyte-specific acetylation-mimetic mutation of PPARγ K293Q (aKQ) restrains adipose plasticity during calorie restriction and diet-induced obesity, associated with proteolysis of a core circadian component BMAL1. Consistently, the rhythmicity in glucose tolerance and insulin sensitivity is altered in aKQ and the complementary PPARγ deacetylation-mimetic K268R/K293R (2KR) mouse models. Furthermore, the PPARγ acetylation-sensitive downstream target adipsin is revealed as a novel diurnal factor that destabilizes BMAL1 and mediates metabolic rhythms. These findings collectively signify that PPARγ acetylation is a hinge connecting adipose plasticity and metabolic rhythms, the two determinants of metabolic health.","journal":"Advanced Science","year":2022,"id":247099,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":35,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9497,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":688616,"name":"Alana Taub","orcid":null,"position":1,"is_corresponding":false},{"id":650404,"name":"Lexiang Yu","orcid":"0009-0004-2782-1025","position":2,"is_corresponding":false},{"id":687900,"name":"Yifan Yao","orcid":"0000-0003-0337-8802","position":3,"is_corresponding":false},{"id":753395,"name":"Ruotong Zhang","orcid":"0000-0002-1484-7769","position":4,"is_corresponding":false},{"id":567590,"name":"Tarik Zahr","orcid":"0000-0002-2754-6092","position":5,"is_corresponding":false},{"id":494830,"name":"Nicole Aaron","orcid":null,"position":6,"is_corresponding":false},{"id":687901,"name":"Joseph LeSauter","orcid":"0000-0002-2963-1901","position":7,"is_corresponding":false},{"id":650407,"name":"Lihong Fan","orcid":"0000-0002-8864-6732","position":8,"is_corresponding":false},{"id":493971,"name":"Longhua Liu","orcid":"0000-0001-6501-863X","position":9,"is_corresponding":false},{"id":885147,"name":"Ruya Tazebay","orcid":null,"position":10,"is_corresponding":false},{"id":75510,"name":"Jianwen Que","orcid":"0000-0002-6540-6701","position":11,"is_corresponding":false},{"id":109694,"name":"Utpal B. Pajvani","orcid":"0000-0001-5991-2723","position":12,"is_corresponding":false},{"id":650405,"name":"Liheng Wang","orcid":"0000-0003-0920-8222","position":13,"is_corresponding":false},{"id":687902,"name":"Rae Silver","orcid":"0000-0001-8633-739X","position":14,"is_corresponding":false},{"id":323933,"name":"Li Qiang","orcid":"0000-0001-8322-1797","position":15,"is_corresponding":false},{"id":650406,"name":"Ying He","orcid":"0000-0003-0110-8497","position":0,"is_corresponding":true}],"reference_count":66,"raw_metadata":null,"created_at":"2026-07-19T00:23:53.369530Z","pmid":"36394167","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}