{"doi":"10.1002/advs.202202771","title":"Nebulized mRNA‐Encoded Antibodies Protect Hamsters from SARS‐CoV‐2 Infection","abstract":"Despite the success of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccines, there remains a clear need for new classes of preventatives for respiratory viral infections due to vaccine hesitancy, lack of sterilizing immunity, and for at-risk patient populations, including the immunocompromised. While many neutralizing antibodies have been identified, and several approved, to treat COVID-19, systemic delivery, large doses, and high costs have the potential to limit their widespread use, especially in low- and middle-income countries. To use these antibodies more efficiently, an inhalable formulation is developed that allows for the expression of mRNA-encoded, membrane-anchored neutralizing antibodies in the lung to mitigate SARS-CoV-2 infections. First, the ability of mRNA-encoded, membrane-anchored, anti-SARS-CoV-2 antibodies to prevent infections in vitro is demonstrated. Next, it is demonstrated that nebulizer-based delivery of these mRNA-expressed neutralizing antibodies potently abrogates disease in the hamster model. Overall, these results support the use of nebulizer-based mRNA expression of neutralizing antibodies as a new paradigm for mitigating respiratory virus infections.","journal":"Advanced Science","year":2022,"id":243427,"datarank":0.5333022092234121,"base_score":3.5553480614894135,"endowment":3.5553480614894135,"self_citation_contribution":0.5333022092234121,"citation_network_contribution":0.0,"self_endowment_contribution":0.5333022092234121,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":34,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9507,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":479187,"name":"Chiara Zurla","orcid":"0000-0001-7285-5508","position":1,"is_corresponding":false},{"id":616104,"name":"Hannah E. Peck","orcid":"0000-0002-2620-5392","position":2,"is_corresponding":false},{"id":875246,"name":"Nichole Orr‐Burks","orcid":"0000-0003-4713-2484","position":3,"is_corresponding":false},{"id":875777,"name":"Jae Yeon Joo","orcid":null,"position":4,"is_corresponding":false},{"id":621421,"name":"Jackelyn Murray","orcid":"0000-0001-6838-3579","position":5,"is_corresponding":false},{"id":682785,"name":"Nathan Holladay","orcid":null,"position":6,"is_corresponding":false},{"id":865298,"name":"Ryan A. Hobbs","orcid":null,"position":7,"is_corresponding":false},{"id":875247,"name":"Younghun Jung","orcid":"0000-0002-5528-4667","position":8,"is_corresponding":false},{"id":875248,"name":"Lorena C. S. Chaves","orcid":"0000-0001-7515-0781","position":9,"is_corresponding":false},{"id":617340,"name":"Laura Rotolo","orcid":null,"position":10,"is_corresponding":false},{"id":480111,"name":"Aaron W. Lifland","orcid":null,"position":11,"is_corresponding":false},{"id":570022,"name":"Alicia K. Olivier","orcid":"0000-0002-6987-0720","position":12,"is_corresponding":false},{"id":537904,"name":"Dapeng Li","orcid":"0000-0002-8232-3094","position":13,"is_corresponding":false},{"id":230387,"name":"Kevin O. Saunders","orcid":"0000-0001-7399-7954","position":14,"is_corresponding":false},{"id":225651,"name":"Gregory D. Sempowski","orcid":"0000-0003-0391-6594","position":15,"is_corresponding":false},{"id":106531,"name":"James E. Crowe","orcid":"0000-0002-0049-1079","position":16,"is_corresponding":false},{"id":96347,"name":"Barton F. Haynes","orcid":"0000-0002-7643-9023","position":17,"is_corresponding":false},{"id":581926,"name":"Eric R. Lafontaine","orcid":null,"position":18,"is_corresponding":false},{"id":621422,"name":"Robert J. Hogan","orcid":"0000-0002-0225-830X","position":19,"is_corresponding":false},{"id":320918,"name":"Philip J. Santangelo","orcid":"0000-0001-7352-0339","position":20,"is_corresponding":false},{"id":320916,"name":"Daryll Vanover","orcid":"0000-0001-8744-5923","position":0,"is_corresponding":true}],"reference_count":33,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:23:16.032700Z","pmid":"36316224","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}