{"doi":"10.1002/advs.202105414","title":"HectoSTAR μLED Optoelectrodes for Large‐Scale, High‐Precision In Vivo Opto‐Electrophysiology","abstract":"Dynamic interactions within and across brain areas underlie behavioral and cognitive functions. To understand the basis of these processes, the activities of distributed local circuits inside the brain of a behaving animal must be synchronously recorded while the inputs to these circuits are precisely manipulated. Even though recent technological advances have enabled such large-scale recording capabilities, the development of the high-spatiotemporal-resolution and large-scale modulation techniques to accompany those recordings has lagged. A novel neural probe is presented in this work that enables simultaneous electrical monitoring and optogenetic manipulation of deep neuronal circuits at large scales with a high spatiotemporal resolution. The \"hectoSTAR\" micro-light-emitting-diode (μLED) optoelectrode features 256 recording electrodes and 128 stimulation μLEDs monolithically integrated on the surface of its four 30-µm thick silicon micro-needle shanks, covering a large volume with 1.3-mm × 0.9-mm cross-sectional area located as deep as 6 mm inside the brain. The use of this device in behaving mice for dissecting long-distance network interactions across cortical layers and hippocampal regions is demonstrated. The recording-and-stimulation capabilities hectoSTAR μLED optoelectrodes enables will open up new possibilities for the cellular and circuit-based investigation of brain functions in behaving animals.","journal":"Advanced Science","year":2022,"id":238295,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":55,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9493,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":263222,"name":"Kanghwan Kim","orcid":"0000-0003-1144-956X","position":1,"is_corresponding":false},{"id":861961,"name":"Nathan Slager","orcid":"0009-0006-6621-7853","position":2,"is_corresponding":false},{"id":861962,"name":"Eunah Ko","orcid":"0000-0002-6185-7070","position":3,"is_corresponding":false},{"id":861963,"name":"Sungjin Oh","orcid":"0000-0003-3511-1555","position":4,"is_corresponding":false},{"id":346730,"name":"Saman Salemizadeh Parizi","orcid":null,"position":5,"is_corresponding":false},{"id":862585,"name":"Blake Hendrix","orcid":null,"position":6,"is_corresponding":false},{"id":263224,"name":"John P. Seymour","orcid":"0000-0002-3783-7838","position":7,"is_corresponding":false},{"id":265264,"name":"Kensall D. Wise","orcid":null,"position":8,"is_corresponding":false},{"id":263225,"name":"György Buzsáki","orcid":"0000-0002-3100-4800","position":9,"is_corresponding":false},{"id":274709,"name":"Antonio Fernández‐Ruiz","orcid":"0000-0001-8481-0796","position":10,"is_corresponding":false},{"id":294969,"name":"Euisik Yoon","orcid":"0000-0002-2127-1200","position":11,"is_corresponding":false},{"id":263223,"name":"Mihály Vöröslakos","orcid":"0000-0002-1022-1355","position":0,"is_corresponding":true}],"reference_count":79,"raw_metadata":null,"created_at":"2026-07-19T00:22:26.932537Z","pmid":"35451232","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}