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More significantly, the entrapped PDE5 inhibitor (PDE5‐i) in this nanoplatform can be enzymatically decomposed into nitric oxide that further combines with ROS to generate RNS, enabling the persistent antitumor effect since RNS features longer lifetime than ROS. Intriguingly, ROS conversion into RNS can help ROS to evade the hypoxia‐induced resistance to ROS‐based antitumor. Eventually, RNS production unlocks robust antitumor performances along with ROS elevation and hypoxia mitigation. Moreover, this extraordinary conversion from ROS into RNS also can act as a general method to solve the short lifetime of ROS.</jats:p>","journal":"Advanced Science","year":2021,"id":666418,"datarank":0.6966586348712059,"base_score":4.6443908991413725,"endowment":4.6443908991413725,"self_citation_contribution":0.6966586348712059,"citation_network_contribution":0.0,"self_endowment_contribution":0.6966586348712059,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":103,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":6,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1429765,"name":"Duo Wang","orcid":"0000-0002-8260-7900","position":1,"is_corresponding":false},{"id":368860,"name":"Lidong Liu","orcid":"0000-0002-7026-690X","position":2,"is_corresponding":false},{"id":367401,"name":"Yan Zhang","orcid":"0000-0002-6041-4454","position":3,"is_corresponding":false},{"id":1740292,"name":"Chuangye Han","orcid":null,"position":4,"is_corresponding":false},{"id":1381047,"name":"Ying Xie","orcid":"0000-0001-5879-8201","position":5,"is_corresponding":false},{"id":418652,"name":"Yan Liu","orcid":"0000-0002-8581-2571","position":6,"is_corresponding":false},{"id":1409982,"name":"Jingchen Liang","orcid":"0000-0001-8888-5234","position":7,"is_corresponding":false},{"id":1740293,"name":"Guanhua Qiu","orcid":null,"position":8,"is_corresponding":false},{"id":1740294,"name":"Hongxue Li","orcid":null,"position":9,"is_corresponding":false},{"id":1613659,"name":"Danke Su","orcid":null,"position":10,"is_corresponding":false},{"id":747038,"name":"Junjie Liu","orcid":"0000-0002-4707-4715","position":11,"is_corresponding":false},{"id":1184841,"name":"Kun Zhang","orcid":"0000-0002-6971-1164","position":12,"is_corresponding":false},{"id":173513,"name":"Tao Luo","orcid":"0000-0001-7146-6121","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Switching Reactive Oxygen Species into Reactive Nitrogen Species by Photocleaved O<sub>2</sub>‐Released Nanoplatforms Favors Hypoxic Tumor Repression","abstract":"<jats:title>Abstract</jats:title><jats:p>In various reactive oxygen species (ROS)‐based antitumor approaches (e.g., photodynamic therapy), increasing attentions are made to improve ROS level, but the short lifetime that is another decisive hurdle of ROS‐based antitumor outcomes is not even explored yet. 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