{"doi":"10.1002/advs.202100166","title":"Synergistic Activation of Antitumor Immunity by a Particulate Therapeutic Vaccine","abstract":"Abstract Success in anticancer immune therapy relies on stimulation of tumor antigen‐specific T lymphocytes and effective infiltration of the T cells into tumor tissue. Here, a therapeutic vaccine that promotes proliferation and tumor infiltration of antigen‐specific T cells in both inflamed and noninflamed tumor types is described. The vaccine consists of STING agonist 2′3′‐cGAMP, TLR9 ligand CpG, and tumor antigen peptides that are loaded into nanoporous microparticles ( μ GCVax). μ GCVax is effective in inhibiting lung metastatic melanoma, primary breast cancer, and subcutaneous colorectal cancer in their respective murine models, including functional cure of HER2‐positive breast cancer. Mechanistically, μ GCVax potently stimulates type I interferon expression in dendritic cells, and promotes CD8 + and CD103 + dendritic cell maturation and migration to lymph nodes and other lymphatic tissues. Antitumor responses are dependent on TLR9 and interferon α / β receptor signaling, and to a less extent on STING signaling. These results demonstrate a high potential for μ GCVax in mediating antitumor immunity in personalized cancer therapy.","journal":"Advanced Science","year":2021,"id":165721,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":35,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9485,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":689573,"name":"Zhaoqi Li","orcid":"0000-0002-3748-8914","position":1,"is_corresponding":false},{"id":689574,"name":"Xiaojun Xia","orcid":"0000-0003-4444-7472","position":2,"is_corresponding":false},{"id":689575,"name":"Jingxin Zhang","orcid":"0000-0002-1520-4300","position":3,"is_corresponding":false},{"id":689576,"name":"Jun Li","orcid":"0009-0001-6196-3965","position":4,"is_corresponding":false},{"id":689577,"name":"Haoran Liu","orcid":"0000-0003-2226-4974","position":5,"is_corresponding":false},{"id":635478,"name":"Jianliang Shen","orcid":null,"position":6,"is_corresponding":false},{"id":689578,"name":"Maricela Ramirez","orcid":"0009-0001-3293-7741","position":7,"is_corresponding":false},{"id":689579,"name":"Feng Li","orcid":"0000-0002-5206-6234","position":8,"is_corresponding":false},{"id":362238,"name":"Zheng Li","orcid":"0000-0001-6118-9175","position":9,"is_corresponding":false},{"id":689580,"name":"Kenji Yokoi","orcid":"0000-0003-2153-9278","position":10,"is_corresponding":false},{"id":319927,"name":"Xuewu Liu","orcid":"0000-0002-8702-0295","position":11,"is_corresponding":false},{"id":245094,"name":"Elizabeth A. Mittendorf","orcid":"0000-0002-9762-8536","position":12,"is_corresponding":false},{"id":57875,"name":"Mauro Ferrari","orcid":null,"position":13,"is_corresponding":false},{"id":57874,"name":"Haifa Shen","orcid":"0000-0002-9728-5430","position":14,"is_corresponding":false},{"id":254274,"name":"Junhua Mai","orcid":"0000-0001-8374-4352","position":0,"is_corresponding":true}],"reference_count":71,"raw_metadata":null,"created_at":"2026-07-18T23:45:40.838485Z","pmid":"34194942","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}