{"doi":"10.1002/adtp.202000138","title":"HDL Nanoparticles Have Wound Healing and Anti‐Inflammatory Properties and Can Topically Deliver miRNAs","abstract":"microRNAs regulate numerous biological processes, making them potential therapeutic agents. Problems with delivery and stability of these molecules have limited their usefulness as treatments. We demonstrate that synthetic high-density lipoprotein nanoparticles (HDL NPs) topically applied to the intact ocular surface are taken up by epithelial and stromal cells. microRNAs complexed to HDL NPs (miR-HDL NPs) are similarly taken up by cells and tissues and retain biological activity. Topical treatment of diabetic mice with either HDL NPs or miR-HDL NPs significantly improved corneal re-epithelialization following wounding compared with controls. Mouse corneas with alkali burn-induced inflammation, topically treated with HDL NPs, displayed clinical, morphological and immunological improvement. These results should yield a novel HDL NP-based eye drop for patients with compromised wound healing ability (diabetics) and/or corneal inflammatory diseases (e.g. dry eye).","journal":"Advanced Therapeutics","year":2020,"id":70650,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9492,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":375225,"name":"Andrea E. Calvert","orcid":null,"position":1,"is_corresponding":false},{"id":323997,"name":"Nihal Kaplan","orcid":"0000-0002-4552-5201","position":2,"is_corresponding":false},{"id":373843,"name":"Kaylin M. McMahon","orcid":"0000-0003-1130-9567","position":3,"is_corresponding":false},{"id":324927,"name":"Wending Yang","orcid":null,"position":4,"is_corresponding":false},{"id":323998,"name":"Kurt Q. Lu","orcid":"0000-0002-8297-433X","position":5,"is_corresponding":false},{"id":323999,"name":"Han Peng","orcid":"0000-0002-1105-8254","position":6,"is_corresponding":false},{"id":373844,"name":"C. Shad Thaxton","orcid":"0000-0002-4765-6213","position":7,"is_corresponding":false},{"id":324000,"name":"Robert M. Lavker","orcid":"0000-0003-2570-9537","position":8,"is_corresponding":false},{"id":373842,"name":"Junyi Wang","orcid":"0000-0003-3985-0822","position":0,"is_corresponding":true}],"reference_count":67,"raw_metadata":null,"created_at":"2026-07-18T21:43:32.585486Z","pmid":"33709017","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}