{"doi":"10.1002/adtp.202000120","title":"Acoustically Driven Microbubbles Enable Targeted Delivery of microRNA‐Loaded Nanoparticles to Spontaneous Hepatocellular Neoplasia in Canines","abstract":"Abstract Spatially localized microbubble cavitation by ultrasound offers an effective means of altering the permeability of natural barriers (i.e., blood vessels and cell membranes) in favor of nanomaterial accumulation in target sites. In this study, a clinically relevant, minimally invasive ultrasound guided therapeutic approach is investigated for the targeted delivery of anticancer microRNA loaded PLGA‐ b ‐PEG nanoparticles to spontaneous hepatocellular neoplasia in a canine model. Quantitative assessment of the delivered microRNAs reveals a prominent and consistent increase in microRNAs levels (1.5‐ to 2.3‐fold increase [ p < 0.001]) in ultrasound treated tumor regions compared to untreated control regions. The immunohistology of ultrasound treated tumor tissue presents clear evidence for a higher amount of nanoparticle extravasation from the blood vessels. A distinct pattern of cytokine expression supporting a CD8+ T cells mediated “cold‐to‐hot” tumor transition is evident in all patients. This proposed platform can enhance delivery of microRNA‐loaded nanoparticles to deeply located visceral tumors in large animals to enhance chemotherapy.","journal":"Advanced Therapeutics","year":2020,"id":89530,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9428,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":376646,"name":"Arsenii Telichko","orcid":"0000-0003-1275-7863","position":1,"is_corresponding":false},{"id":376647,"name":"Huaijun Wang","orcid":"0000-0002-2933-6566","position":2,"is_corresponding":false},{"id":452710,"name":"Dongwoon Hyun","orcid":"0000-0003-2625-8109","position":3,"is_corresponding":false},{"id":452711,"name":"Eric G. Johnson","orcid":"0000-0002-3059-4052","position":4,"is_corresponding":false},{"id":393154,"name":"Michael S. Kent","orcid":"0000-0002-7703-7720","position":5,"is_corresponding":false},{"id":288712,"name":"Robert B. Rebhun","orcid":"0000-0002-8047-3494","position":6,"is_corresponding":false},{"id":284657,"name":"Jeremy Dahl","orcid":"0000-0001-9877-452X","position":7,"is_corresponding":false},{"id":393153,"name":"William T. N. Culp","orcid":"0000-0001-6132-156X","position":8,"is_corresponding":false},{"id":292426,"name":"Ramasamy Paulmurugan","orcid":"0000-0001-7155-4738","position":9,"is_corresponding":false},{"id":292420,"name":"Uday Kumar Sukumar","orcid":"0000-0002-0354-2353","position":0,"is_corresponding":true}],"reference_count":67,"raw_metadata":null,"created_at":"2026-07-18T22:02:27.195966Z","pmid":"33415184","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}