{"doi":"10.1002/adtp.202000094","title":"Robust Anti‐Tumor T Cell Response with Efficient Intratumoral Infiltration by Nanodisc Cancer Immunotherapy","abstract":"Potent anti-tumor T cell response and efficient intratumoral T cell infiltration are the major challenges for therapeutic cancer vaccines. To address these issues, a nano-vaccine system has been designed to promote anti-tumor T cell responses, and intratumoral infiltration was examined in various murine tumor models. Subcutaneous vaccination with nanodiscs carrying human papillomavirus (HPV)-16 E7 antigen elicits as high as ~32% E7-specific CD8 α + T cell responses in circulation, representing a 29-fold improvement over the soluble peptide vaccination. Importantly, nanodisc vaccination also promotes robust intratumoral T cell infiltration and eliminates HPV16 E6/E7-expressing TC-1 tumors at mucosal sites, including lungs, inner lip, and intravaginal tissues. In a benchmark study with a live Listeria vaccine combined with anti-PD-1 IgG, nanodiscs plus anti-PD-1 immune checkpoint blockade elicits comparable levels of T cell responses with anti-tumor efficacy. Furthermore, compared with Complete Freund's Adjuvant combined with tetanus toxoid, nanodisc vaccination in HLA-A02 mice generates >200-fold stronger IFN-γ+ T cell responses against a neoantigen from an HLA-A02 melanoma patient. Overall, these results show that the nanodisc system is a promising cancer vaccine platform for inducing anti-tumor T cell responses.","journal":"Advanced Therapeutics","year":2020,"id":75374,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9561,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":394290,"name":"Priti B. Singh","orcid":null,"position":1,"is_corresponding":false},{"id":298044,"name":"Xiaoqi Sun","orcid":"0000-0003-0752-1928","position":2,"is_corresponding":false},{"id":337059,"name":"Cheng Xu","orcid":"0000-0003-1000-733X","position":3,"is_corresponding":false},{"id":249122,"name":"Alireza Hassani Najafabadi","orcid":"0000-0002-8215-4374","position":4,"is_corresponding":false},{"id":298043,"name":"Lindsay Scheetz","orcid":"0000-0002-3201-367X","position":5,"is_corresponding":false},{"id":349983,"name":"Wenmin Yuan","orcid":"0000-0002-0250-4072","position":6,"is_corresponding":false},{"id":393364,"name":"Yao Xu","orcid":"0000-0001-7528-6646","position":7,"is_corresponding":false},{"id":393365,"name":"Hao Hong","orcid":"0000-0002-9730-9367","position":8,"is_corresponding":false},{"id":25296,"name":"Derin B. Keskin","orcid":"0000-0002-8496-6181","position":9,"is_corresponding":false},{"id":3263,"name":"Catherine J. Wu","orcid":"0000-0002-3348-5054","position":10,"is_corresponding":false},{"id":393366,"name":"Renu Jain","orcid":"0000-0003-2304-3081","position":11,"is_corresponding":false},{"id":298046,"name":"Anna Schwendeman","orcid":"0000-0002-8023-8080","position":12,"is_corresponding":false},{"id":249124,"name":"James J. Moon","orcid":"0000-0003-2238-2372","position":13,"is_corresponding":false},{"id":109089,"name":"Rui Kuai","orcid":"0000-0003-2324-1272","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-18T21:46:33.313355Z","pmid":"38317797","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}