{"doi":"10.1002/admt.202500429","title":"Multiplexed Luminal Tissue Constructs with Reconfigurable Barriers for Dynamic Modeling of Multi‐Tissue Interactions","abstract":"models, but conventional systems struggle with their geometrical complexity. While recent microengineering and self-assembly platforms have shown promise, they face limitations in throughput, equipment compatibility, and operational complexity. To address these challenges, we have developed an array of three-dimensional tissue constructs with luminal structures that overcome current limitations. Our platform employs a sacrificial micromolding technique to generate arrays of luminal structures within extracellular matrix hydrogels in a single process, improving throughput. We also incorporate a reconfigurable oil barrier between tissue compartments, enabling dynamic modeling of multi-tissue interactions. This approach reduces fabrication complexity, increases robustness, and offers high flexibility in arranging multi-tissue constructs. The platform allows formation of multiple luminal structures and tissue configurations, discrete compartmentalization for parallel experiments, and reconfiguration of the oil barrier to study physiological multi-tissue interactions. By facilitating complex microtissue cultures and multi-tissue experiments on a single device, our platform presents a promising technology for multi-organ modeling research and drug discovery applications.","journal":"Advanced Materials Technologies","year":2025,"id":535617,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9457,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1419746,"name":"José A. Jiménez‐Torres","orcid":null,"position":1,"is_corresponding":false},{"id":321489,"name":"Chao Li","orcid":"0000-0002-1126-0655","position":2,"is_corresponding":false},{"id":282369,"name":"José M. Ayuso","orcid":"0000-0002-9414-1845","position":3,"is_corresponding":false},{"id":282367,"name":"Karina M. Lugo-Cintrón","orcid":"0000-0002-9661-8897","position":4,"is_corresponding":false},{"id":1419747,"name":"Joseph Ulbrich","orcid":null,"position":5,"is_corresponding":false},{"id":317641,"name":"Benjamin Myers","orcid":"0000-0001-7378-692X","position":6,"is_corresponding":false},{"id":401581,"name":"Sheena C. Kerr","orcid":"0000-0002-4404-3382","position":7,"is_corresponding":false},{"id":686472,"name":"Adeel Ahmed","orcid":"0000-0003-4511-8208","position":8,"is_corresponding":false},{"id":282370,"name":"David J. Beebe","orcid":"0000-0002-0415-9006","position":9,"is_corresponding":false},{"id":302974,"name":"Mouhita Humayun","orcid":"0000-0003-0749-2725","position":0,"is_corresponding":true}],"reference_count":63,"raw_metadata":null,"created_at":"2026-07-19T02:51:56.297114Z","pmid":"41693925","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}