{"doi":"10.1002/admi.202400005","title":"An Advanced Healthcare Sensing Platform for Direct Detection of Viral Proteins in Seconds at Femtomolar Concentrations via Aerosol Jet 3D‐Printed Nano and Biomaterials","abstract":"Sensing of viral antigens has become a critical tool in combating infectious diseases. Current sensing techniques have a tradeoff between sensitivity and time of detection; with 10-30 min of detection time at a relatively low sensitivity and 6-12 h of detection at a high (picomolar) sensitivity. In this research, uniquely nanoengineered interfaces are demonstrated on 3D electrodes that enable the detection of spike antigens of SARS-CoV-2 and their variants in seconds at femtomolar concentrations with excellent specificity, thus, overcoming this tradeoff. The 3D electrodes, manufactured using a high-resolution aerosol jet 3D nanoprinter, consist of a microelectrode array of sintered gold nanoparticles coated with graphene and antibodies specific to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike antigens. An impedance-based sensing modality is employed to sense several pseudoviruses of SARS-CoV-2 variants of concern (VOCs). This device is sensitive to most of the pseudoviruses of SARS-CoV-2 VOCs. A high sensitivity of 100 fm, along with a low limit-of-detection of 9.2 fm within a test range of 0.1-1000 pm, and a detection time of 43 s are shown. This work illustrates that effective nano-bioengineering of interfaces can be used to create an ultrafast and ultrasensitive healthcare diagnostic tool for combating emerging infections.","journal":"Advanced Materials Interfaces","year":2024,"id":424092,"datarank":0.47032413238937254,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"self_citation_contribution":0.47032413238937254,"citation_network_contribution":0.0,"self_endowment_contribution":0.47032413238937254,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9527,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":892933,"name":"Fei Zhang","orcid":"0009-0008-7957-5937","position":1,"is_corresponding":false},{"id":626909,"name":"Chunshan Hu","orcid":null,"position":2,"is_corresponding":false},{"id":892934,"name":"Bin Yuan","orcid":"0000-0002-4021-6186","position":3,"is_corresponding":false},{"id":304016,"name":"Shou‐Jiang Gao","orcid":"0000-0001-6194-1742","position":4,"is_corresponding":false},{"id":625660,"name":"Rahul Panat","orcid":"0000-0002-4824-2936","position":5,"is_corresponding":false},{"id":892932,"name":"Md. Azahar Ali","orcid":"0000-0001-5752-8808","position":0,"is_corresponding":true}],"reference_count":71,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:58:07.191194Z","pmid":"40808895","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}