{"doi":"10.1002/admi.202201261","title":"Gold Nanoparticle Enabled Localized Surface Plasmon Resonance on Unique Gold Nanomushroom Structures for On‐Chip CRISPR‐Cas13a Sensing","abstract":"A novel localized surface plasmon resonance (LSPR) system based on the coupling of gold nanomushrooms (AuNMs) and gold nanoparticles (AuNPs) is developed to enable a significant plasmonic resonant shift. The AuNP size, surface chemistry, and concentration are characterized to maximize the LSPR effect. A 31 nm redshift is achieved when the AuNMs are saturated by the AuNPs. This giant redshift also increases the full width of the spectrum and is explained by the 3D finite-difference time-domain (FDTD) calculation. In addition, this LSPR substrate is packaged in a microfluidic cell and integrated with a CRISPR-Cas13a RNA detection assay for the detection of the SARS-CoV-2 RNA targets. Once activated by the target, the AuNPs are cleaved from linker probes and randomly deposited on the AuNM substrate, demonstrating a large redshift. The novel LSPR chip using AuNP as an indicator is simple, specific, isothermal, and label-free; and thus, provides a new opportunity to achieve the next generation multiplexing and sensitive molecular diagnostic system.","journal":"Advanced Materials Interfaces","year":2022,"id":242451,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":38,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9463,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":872936,"name":"Yu Chang","orcid":"0000-0003-1490-1961","position":1,"is_corresponding":false},{"id":872937,"name":"Li Liu","orcid":"0000-0003-2560-3281","position":2,"is_corresponding":false},{"id":872938,"name":"Srinivasu Valagerahally Puttaswamy","orcid":"0000-0003-2208-7496","position":3,"is_corresponding":false},{"id":873101,"name":"Taerin Chung","orcid":null,"position":4,"is_corresponding":false},{"id":832410,"name":"Adrian M. Molina Vargas","orcid":"0000-0003-4090-1180","position":5,"is_corresponding":false},{"id":467332,"name":"Stephen J. Dollery","orcid":"0000-0002-1712-3811","position":6,"is_corresponding":false},{"id":422293,"name":"Mitchell R. O’Connell","orcid":"0000-0002-8642-3973","position":7,"is_corresponding":false},{"id":309178,"name":"Haogang Cai","orcid":"0000-0003-1700-2531","position":8,"is_corresponding":false},{"id":467329,"name":"Gregory J. Tobin","orcid":"0000-0002-8396-0466","position":9,"is_corresponding":false},{"id":872939,"name":"Nikhil Bhalla","orcid":"0000-0002-4720-3679","position":10,"is_corresponding":false},{"id":732281,"name":"Ke Du","orcid":"0000-0002-6837-0927","position":11,"is_corresponding":false},{"id":873465,"name":"Jacob Waitkus","orcid":null,"position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-19T00:23:05.485568Z","pmid":"37091050","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}