{"doi":"10.1002/adma.202416696","title":"Interpretable Radiomics Model Predicts Nanomedicine Tumor Accumulation Using Routine Medical Imaging","abstract":"<jats:title>Abstract</jats:title><jats:p>Accurately predicting nanomedicine accumulation is critical for guiding patient stratification and optimizing treatment strategies in the context of precision medicine. However, non‐invasive prediction of nanomedicine accumulation remains challenging, primarily due to the complexity of identifying relevant imaging features that predict accumulation. Here, a novel non‐invasive method is proposed that utilizes standard‐of‐care medical imaging modalities, including computed tomography and ultrasound, combined with a radiomics‐based model to predict nanomedicine accumulation in tumor. The model is validated using a test dataset consisting of seven tumor xenografts in mice and three sizes of gold nanoparticles, achieving an area under the receiver operating characteristic curve of 0.851. The median accumulation levels of tumors predicted as “high accumulators” are 2.69 times greater than those predicted as “low accumulators”. Analysis of this machine‐learning‐driven interpretable radiomics model revealed imaging features that are strongly correlated with dense stroma, a recognized biological barrier to effective nanomedicine delivery. Radiomics‐based prediction of tumor accumulation holds promise for stratifying patient and enabling precise tailoring of nanomedicine treatment strategies.</jats:p>","journal":"Advanced Materials","year":2025,"id":664091,"datarank":0.49670390686636934,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.12396790939816921,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.12396790939816921,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":11,"citers_with_citation_signal":7,"citers_with_endowment":7,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":322630,"name":"Jie Zhang","orcid":"0000-0002-9941-1568","position":1,"is_corresponding":false},{"id":530630,"name":"Yang Li","orcid":"0000-0002-6065-4706","position":2,"is_corresponding":false},{"id":1733968,"name":"Yongzhi Hu","orcid":null,"position":3,"is_corresponding":false},{"id":1733969,"name":"Doudou He","orcid":null,"position":4,"is_corresponding":false},{"id":922976,"name":"Hao Ni","orcid":"0000-0001-5485-4376","position":5,"is_corresponding":false},{"id":1733970,"name":"Jiulou Zhang","orcid":null,"position":6,"is_corresponding":false},{"id":1505322,"name":"Feiyun Wu","orcid":null,"position":7,"is_corresponding":false},{"id":703709,"name":"Yuxia Tang","orcid":"0000-0002-0040-6145","position":8,"is_corresponding":false},{"id":1660461,"name":"Shouju Wang","orcid":"0000-0001-9213-6818","position":9,"is_corresponding":false},{"id":1591265,"name":"Jiajia Tang","orcid":"0009-0004-3352-4043","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Interpretable Radiomics Model Predicts Nanomedicine Tumor Accumulation Using Routine Medical Imaging","abstract":"<jats:title>Abstract</jats:title><jats:p>Accurately predicting nanomedicine accumulation is critical for guiding patient stratification and optimizing treatment strategies in the context of precision medicine. However, non‐invasive prediction of nanomedicine accumulation remains challenging, primarily due to the complexity of identifying relevant imaging features that predict accumulation. Here, a novel non‐invasive method is proposed that utilizes standard‐of‐care medical imaging modalities, including computed tomography and ultrasound, combined with a radiomics‐based model to predict nanomedicine accumulation in tumor. The model is validated using a test dataset consisting of seven tumor xenografts in mice and three sizes of gold nanoparticles, achieving an area under the receiver operating characteristic curve of 0.851. The median accumulation levels of tumors predicted as “high accumulators” are 2.69 times greater than those predicted as “low accumulators”. Analysis of this machine‐learning‐driven interpretable radiomics model revealed imaging features that are strongly correlated with dense stroma, a recognized biological barrier to effective nanomedicine delivery. Radiomics‐based prediction of tumor accumulation holds promise for stratifying patient and enabling precise tailoring of nanomedicine treatment strategies.</jats:p>","is_dataset_classified":null,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39916575","pmcid":null,"openalex_id":"https://openalex.org/W4407233707","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"82372019","title":null},{"funder_name":"Engineering and Physical Sciences Research Council","grant_id":"EP/S026347/1","title":"Unparameterised multi-modal data, high order signatures, and the mathematics of data science"},{"funder_name":"Alan Turing Institute","grant_id":"EP/N510129/1","title":null},{"funder_name":"China Pharmaceutical University","grant_id":"CPUQNJC22_03","title":null}],"total_grants":4,"fwci":7.1773,"citation_percentile":0.97462244,"influential_citations":0,"citation_trend":[{"year":2025,"count":5},{"year":2026,"count":6}],"oa_status":"bronze","license":"Wiley Online Library User Agreement","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adma.202416696","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adma.202416696","host_type":"publisher"},{"url":"https://advanced.onlinelibrary.wiley.com/doi/pdf/10.1002/adma.202416696","host_type":"publisher"},{"url":"https://doi.org/10.1002/adma.202416696","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39916575","host_type":"repository"},{"url":"https://discovery.ucl.ac.uk/id/eprint/10204523/","host_type":"repository"},{"url":"https://discovery.ucl.ac.uk/id/eprint/10204523/3/Ni_AM_Manuscript-clear-accepted%20version.pdf","host_type":"repository"}],"fields_of_study":["Radiomics and Machine Learning in Medical Imaging","Pancreatic and Hepatic Oncology Research","Sarcoma Diagnosis and Treatment","02 engineering and technology","0210 nano-technology"],"mesh_terms":["Machine Learning","Radiomics","Animals","Diagnostic Imaging","Gold","Humans","Neoplasms","Tomography, X-Ray Computed","Ultrasonography","Cell Line, Tumor","Nanomedicine","Mice","Metal Nanoparticles"],"keywords":["Nanomedicine","Radiomics","Medical imaging","Context (archaeology)","Personalized medicine","Precision medicine","Materials science","Artificial intelligence","Medical physics","Biomedical engineering","Computer science","Nanotechnology","Medicine","Nanoparticle","Bioinformatics","Pathology","Machine Learning","Nanomedicine Accumulation","Metal Nanoparticles","Mice","Neoplasms","Cell Line, Tumor","Animals","Humans","Gold","Tomography, X-Ray Computed","Ultrasonography"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-13T01:07:05.392641Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}