{"doi":"10.1002/adma.202409618","title":"Ultrasmall Enzyodynamic PANoptosis Nano‐Inducers for Ultrasound‐Amplified Hepatocellular Carcinoma Therapy and Lung Metastasis Inhibition","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>\n                    Addressing the inefficiency of current therapeutic approaches for hepatocellular carcinoma is an urgent and pressing challenge. PANoptosis, a form of inflammatory programmed cell death, presents a dependable strategy for combating cancer by engaging multiple cell death pathways (apoptosis, pyroptosis, and necroptosis). In this study, an ultrasmall Bi\n                    <jats:sub>2</jats:sub>\n                    Sn\n                    <jats:sub>2</jats:sub>\n                    O\n                    <jats:sub>7</jats:sub>\n                    nanozyme with ultrasound‐magnified multienzyme‐mimicking properties is designed and engineered as a PANoptosis inducer through destroying the mitochondrial function of tumor cells and enhancing the intracellular accumulation of toxic reactive oxygen species, finally triggering the activation of PANoptosis process. The role of PANoptosis inducer has been verified by the expression of related proteins, including cleaved Caspase 3, NLRP3, N‐GSDMD, cleaved Caspase 1, p‐MLKL, and RIPK3. The inclusion of external ultrasonic irradiation significantly augments the enzyodynamic therapeutic efficiency. In vitro and in vivo antineoplastic efficacy, along with inhibition of lung metastasis, validate the benefits of the Bi\n                    <jats:sub>2</jats:sub>\n                    Sn\n                    <jats:sub>2</jats:sub>\n                    O\n                    <jats:sub>7</jats:sub>\n                    ‐mediated PANoptosis pathway. This study not only elucidates the intricate mechanisms underlying Bi\n                    <jats:sub>2</jats:sub>\n                    Sn\n                    <jats:sub>2</jats:sub>\n                    O\n                    <jats:sub>7</jats:sub>\n                    as a PANoptosis inducer, but also offers a novel perspective for the treatment of hepatocellular carcinoma.\n                  </jats:p>","journal":"Advanced Materials","year":2024,"id":609250,"datarank":0.6166310796259968,"base_score":4.110873864173311,"endowment":4.110873864173311,"self_citation_contribution":0.6166310796259968,"citation_network_contribution":0.0,"self_endowment_contribution":0.6166310796259968,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":60,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":640489,"name":"Hai Wang","orcid":"0000-0002-1292-998X","position":1,"is_corresponding":false},{"id":1565819,"name":"Chunrong Ren","orcid":null,"position":2,"is_corresponding":false},{"id":1565820,"name":"Ruxi Deng","orcid":null,"position":3,"is_corresponding":false},{"id":1565821,"name":"Qiaoxi Qin","orcid":null,"position":4,"is_corresponding":false},{"id":1463550,"name":"Li Ding","orcid":"0000-0002-0967-7021","position":5,"is_corresponding":false},{"id":1165994,"name":"Pan Li","orcid":"0009-0000-0612-6331","position":6,"is_corresponding":false},{"id":320344,"name":"Ying Liu","orcid":"0000-0002-4966-3476","position":7,"is_corresponding":false},{"id":1565822,"name":"Meiqi Chang","orcid":null,"position":8,"is_corresponding":false},{"id":1149062,"name":"Yu Chen","orcid":"0000-0002-8206-3325","position":9,"is_corresponding":false},{"id":255650,"name":"Yang Zhou","orcid":"0000-0002-1342-9952","position":10,"is_corresponding":false},{"id":1565818,"name":"Wuyang Wei","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Ultrasmall Enzyodynamic PANoptosis Nano‐Inducers for Ultrasound‐Amplified Hepatocellular Carcinoma Therapy and Lung Metastasis Inhibition","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>\n                    Addressing the inefficiency of current therapeutic approaches for hepatocellular carcinoma is an urgent and pressing challenge. PANoptosis, a form of inflammatory programmed cell death, presents a dependable strategy for combating cancer by engaging multiple cell death pathways (apoptosis, pyroptosis, and necroptosis). In this study, an ultrasmall Bi\n                    <jats:sub>2</jats:sub>\n                    Sn\n                    <jats:sub>2</jats:sub>\n                    O\n                    <jats:sub>7</jats:sub>\n                    nanozyme with ultrasound‐magnified multienzyme‐mimicking properties is designed and engineered as a PANoptosis inducer through destroying the mitochondrial function of tumor cells and enhancing the intracellular accumulation of toxic reactive oxygen species, finally triggering the activation of PANoptosis process. The role of PANoptosis inducer has been verified by the expression of related proteins, including cleaved Caspase 3, NLRP3, N‐GSDMD, cleaved Caspase 1, p‐MLKL, and RIPK3. The inclusion of external ultrasonic irradiation significantly augments the enzyodynamic therapeutic efficiency. In vitro and in vivo antineoplastic efficacy, along with inhibition of lung metastasis, validate the benefits of the Bi\n                    <jats:sub>2</jats:sub>\n                    Sn\n                    <jats:sub>2</jats:sub>\n                    O\n                    <jats:sub>7</jats:sub>\n                    ‐mediated PANoptosis pathway. This study not only elucidates the intricate mechanisms underlying Bi\n                    <jats:sub>2</jats:sub>\n                    Sn\n                    <jats:sub>2</jats:sub>\n                    O\n                    <jats:sub>7</jats:sub>\n                    as a PANoptosis inducer, but also offers a novel perspective for the treatment of hepatocellular carcinoma.\n                  </jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39225412","pmcid":null,"openalex_id":null,"authors":[],"funders":[{"funder_name":"Shanghai Shuguang Program","grant_id":"21SG39","title":null},{"funder_name":"Key Research and Development Program of Sichuan Province","grant_id":"2024YFHZ0078","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"81971636","title":null},{"funder_name":"National Key Research and Development Projects","grant_id":"2023YFC2306500","title":null},{"funder_name":"Shanghai Science and Technology Program","grant_id":"21010500100","title":null},{"funder_name":"Basic Research Program of Shanghai Municipal Government","grant_id":"21JC1406002","title":null},{"funder_name":"Third People's Hospital of Chengdu Scientific Research Project","grant_id":"CSY-YN-01-2023-004","title":null},{"funder_name":"Third People's Hospital of Chengdu Scientific Research Project","grant_id":"2023PI03","title":null}],"total_grants":8,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"http://doi.wiley.com/10.1002/tdm_license_1.1","oa_locations":[{"url":"https://advanced.onlinelibrary.wiley.com/doi/pdf/10.1002/adma.202409618","host_type":"publisher"},{"url":"https://advanced.onlinelibrary.wiley.com/doi/full-xml/10.1002/adma.202409618","host_type":"publisher"}],"fields_of_study":["Carcinoma, Hepatocellular","Liver Neoplasms","Humans","Lung Neoplasms","Animals","Mice","Cell Line, Tumor","Necroptosis","Reactive Oxygen Species","Ultrasonic Therapy","Ultrasonic Waves","Nanoparticles","Antineoplastic Agents","Apoptosis","Sulfides"],"mesh_terms":["Carcinoma, Hepatocellular","Liver Neoplasms","Humans","Lung Neoplasms","Animals","Mice","Cell Line, Tumor","Necroptosis","Reactive Oxygen Species","Ultrasonic Therapy","Ultrasonic Waves","Nanoparticles","Antineoplastic Agents","Apoptosis","Sulfides"],"keywords":["PANoptosis","lung metastasis","multienzyme‐mimicking activity","nanozyme","ultrasound therapy"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-31T05:11:07.142429Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}