{"doi":"10.1002/adma.202407189","title":"Systemic Multifunctional Nanovaccines for Potent Personalized Immunotherapy of Acute Myeloid Leukemia","abstract":"<jats:title>Abstract</jats:title><jats:p>Hematological malignancies (HM) like acute myeloid leukemia (AML) are often intractable. Cancer vaccines possibly inducing robust and broad anti‐tumor immune responses may be a promising treatment option for HM. Few effective vaccines against blood cancers are, however, developed to date partly owing to insufficient stimulation of dendritic cells (DCs) in the body and lacking appropriate tumor antigens (Ags). Here it is found that systemic multifunctional nanovaccines consisting of nucleotide‐binding oligomerization domain‐containing protein 2 (NOD2) and Toll‐like receptor 9 (TLR9) agonists – muramyl dipeptide (MDP) and CpG, and tumor cell lysate (TCL) as Ags (MCA‐NV) induce potent and broad immunity against AML. MCA‐NV show complementary stimulation of DCs and prime homing to lymphoid organs following systemic administration. Of note, in orthotopic AML mouse models, intravenous infusion of different vaccine formulations elicits substantially higher anti‐AML efficacies than subcutaneous administration. Systemic MCA‐NV cure 78% of AML mice and elicit long‐term immune memory with 100% protection from rechallenging AML cells. Systemic MCA‐NV can also serve as prophylactic vaccines against the same AML. These systemic nanovaccines utilizing patient TCL as Ags and dual adjuvants to elicit strong, durable, and broad immune responses can provide a personalized immunotherapeutic strategy against AML and other HM.</jats:p>","journal":"Advanced Materials","year":2024,"id":612774,"datarank":0.4887144807032224,"base_score":3.258096538021482,"endowment":3.258096538021482,"self_citation_contribution":0.4887144807032224,"citation_network_contribution":0.0,"self_endowment_contribution":0.4887144807032224,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1577914,"name":"Tanzhen Wang","orcid":null,"position":1,"is_corresponding":false},{"id":1577915,"name":"Guanhong Cui","orcid":null,"position":2,"is_corresponding":false},{"id":1577916,"name":"Ruonan Ye","orcid":null,"position":3,"is_corresponding":false},{"id":1577917,"name":"Wenjun Wan","orcid":null,"position":4,"is_corresponding":false},{"id":549948,"name":"Tianhui Liu","orcid":"0000-0001-6789-3016","position":5,"is_corresponding":false},{"id":1245232,"name":"Yiran Zheng","orcid":"0000-0001-7436-8631","position":6,"is_corresponding":false},{"id":1138321,"name":"Zhiyuan Zhong","orcid":"0000-0003-4175-4741","position":7,"is_corresponding":false},{"id":406991,"name":"Peng Zhang","orcid":"0000-0001-8071-3729","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Systemic Multifunctional Nanovaccines for Potent Personalized Immunotherapy of Acute Myeloid Leukemia","abstract":"<jats:title>Abstract</jats:title><jats:p>Hematological malignancies (HM) like acute myeloid leukemia (AML) are often intractable. Cancer vaccines possibly inducing robust and broad anti‐tumor immune responses may be a promising treatment option for HM. Few effective vaccines against blood cancers are, however, developed to date partly owing to insufficient stimulation of dendritic cells (DCs) in the body and lacking appropriate tumor antigens (Ags). Here it is found that systemic multifunctional nanovaccines consisting of nucleotide‐binding oligomerization domain‐containing protein 2 (NOD2) and Toll‐like receptor 9 (TLR9) agonists – muramyl dipeptide (MDP) and CpG, and tumor cell lysate (TCL) as Ags (MCA‐NV) induce potent and broad immunity against AML. MCA‐NV show complementary stimulation of DCs and prime homing to lymphoid organs following systemic administration. Of note, in orthotopic AML mouse models, intravenous infusion of different vaccine formulations elicits substantially higher anti‐AML efficacies than subcutaneous administration. Systemic MCA‐NV cure 78% of AML mice and elicit long‐term immune memory with 100% protection from rechallenging AML cells. Systemic MCA‐NV can also serve as prophylactic vaccines against the same AML. These systemic nanovaccines utilizing patient TCL as Ags and dual adjuvants to elicit strong, durable, and broad immune responses can provide a personalized immunotherapeutic strategy against AML and other HM.</jats:p>","is_dataset_classified":null,"base_score":3.258096538021482,"endowment":3.258096538021482,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39171954","pmcid":null,"openalex_id":"https://openalex.org/W4401738974","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"52233007","title":null},{"funder_name":"National Key Research and Development Program of China","grant_id":"2021YFB3800900","title":null},{"funder_name":"National Key Research and Development Program of China","grant_id":"2022YFA1206002","title":null},{"funder_name":"National Key Research and Development Program of China","grant_id":"2022YFC2502700","title":null},{"funder_name":"Translational Research Grant of NCRCH","grant_id":"2021ZKMB01","title":null},{"funder_name":"Excellent Youth Science Fund of Jiangsu Province","grant_id":"BK20211553","title":null},{"funder_name":"\"Open Competition to Select the Best Candidates\" Key Technology Program for Cell Therapy of NCTIB","grant_id":"NCTIB2023XB02012","title":null},{"funder_name":"Interdisciplinary Basic Frontier Innovation Program of Suzhou Medical College of Soochow University","grant_id":"YXY2301005","title":null}],"total_grants":8,"fwci":3.9132,"citation_percentile":0.9469393,"influential_citations":0,"citation_trend":[{"year":2024,"count":3},{"year":2025,"count":17},{"year":2026,"count":5}],"oa_status":"bronze","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adma.202407189","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adma.202407189","host_type":"publisher"},{"url":"https://advanced.onlinelibrary.wiley.com/doi/pdf/10.1002/adma.202407189","host_type":"publisher"},{"url":"https://doi.org/10.1002/adma.202407189","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39171954","host_type":"repository"}],"fields_of_study":["Immunotherapy and Immune Responses","RNA Interference and Gene Delivery","Immune Cell Function and Interaction"],"mesh_terms":["Nanovaccines","Animals","Antigens, Neoplasm","Dendritic Cells","Humans","Immunotherapy","Leukemia, Myeloid, Acute","Cancer Vaccines","Cell Line, Tumor","Mice","Nod2 Signaling Adaptor Protein","Nanoparticles","Precision Medicine"],"keywords":["Muramyl dipeptide","Systemic administration","Myeloid leukemia","Immune system","TLR9","Immunology","Cancer research","Myeloid","Immunotherapy","Medicine","Cancer immunotherapy","Biology","Gene","Acute myeloid leukemia","Personalized Vaccine","Nanovaccine","Intracellular Codelivery Of Antigens And Adjuvants"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T04:55:04.849791Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}