{"doi":"10.1002/adma.202404606","title":"3D‐Printed Latticed Microneedle Array Patches for Tunable and Versatile Intradermal Delivery","abstract":"Using high-resolution 3D printing, a novel class of microneedle array patches (MAPs) is introduced, called latticed MAPs (L-MAPs). Unlike most MAPs which are composed of either solid structures or hollow needles, L-MAPs incorporate tapered struts that form hollow cells capable of trapping liquid droplets. The lattice structures can also be coated with traditional viscous coating formulations, enabling both liquid- and solid-state cargo delivery, on a single patch. Here, a library of 43 L-MAP designs is generated and in-silico modeling is used to down-select optimal geometries for further characterization. Compared to traditionally molded and solid-coated MAPs, L-MAPs can load more cargo with fewer needles per patch, enhancing cargo loading and drug delivery capabilities. Further, L-MAP cargo release kinetics into the skin can be tuned based on formulation and needle geometry. In this work, the utility of L-MAPs as a platform is demonstrated for the delivery of small molecules, mRNA lipid nanoparticles, and solid-state ovalbumin protein. In addition, the production of programmable L-MAPs is demonstrated with tunable cargo release profiles, enabled by combining needle geometries on a single patch.","journal":"Advanced Materials","year":2024,"id":421688,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":29,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9565,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1214597,"name":"Jihyun Hwang","orcid":"0000-0003-4707-4392","position":1,"is_corresponding":false},{"id":1214598,"name":"Yue Xu","orcid":"0000-0001-7672-9170","position":2,"is_corresponding":false},{"id":323578,"name":"Max A. Saccone","orcid":"0000-0003-3846-2908","position":3,"is_corresponding":false},{"id":1214599,"name":"Andy H. Hung","orcid":"0000-0003-0182-5648","position":4,"is_corresponding":false},{"id":1215197,"name":"Rosa A.S. Hernandez","orcid":null,"position":5,"is_corresponding":false},{"id":1214600,"name":"Ian A. Coates","orcid":"0000-0002-8853-1505","position":6,"is_corresponding":false},{"id":1215198,"name":"Madison M. Driskill","orcid":null,"position":7,"is_corresponding":false},{"id":1214601,"name":"Maria T. Dulay","orcid":"0000-0002-4678-3480","position":8,"is_corresponding":false},{"id":1214602,"name":"Gunilla B. Jacobson","orcid":"0000-0001-6860-5258","position":9,"is_corresponding":false},{"id":400499,"name":"Shaomin Tian","orcid":"0000-0001-5220-3887","position":10,"is_corresponding":false},{"id":598431,"name":"Jillian L. Perry","orcid":"0000-0002-2837-8131","position":11,"is_corresponding":false},{"id":542845,"name":"Joseph M. DeSimone","orcid":"0000-0002-1764-8634","position":12,"is_corresponding":false},{"id":849287,"name":"Netra U. Rajesh","orcid":"0000-0003-0277-6120","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-07-19T01:57:41.370244Z","pmid":"39221508","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}