{"doi":"10.1002/adma.202309412","title":"Bioengineered Ionic Liquid for Catheter‐Directed Tissue Ablation, Drug Delivery, and Embolization","abstract":"Delivery of therapeutics to solid tumors with high bioavailability remains a challenge and is likely the main contributor to the ineffectiveness of immunotherapy and chemotherapy. Here, a catheter-directed ionic liquid embolic (ILE) is bioengineered to achieve durable vascular embolization, uniform tissue ablation, and drug delivery in non-survival and survival porcine models of embolization, outperforming the clinically used embolic agents. To simulate the clinical scenario, rabbit VX2 orthotopic liver tumors are treated showing successful trans-arterial delivery of Nivolumab and effective tumor ablation. Furthermore, similar results are also observed in human ex vivo tumor tissue as well as significant susceptibility of highly resistant patient-derived bacteria is seen to ILE, suggesting that ILE can prevent abscess formation in embolized tissue. ILE represents a new class of liquid embolic agents that can treat tumors, improve the delivery of therapeutics, prevent infectious complications, and potentially increase chemo- and immunotherapy response in solid tumors.","journal":"Advanced Materials","year":2024,"id":430544,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9423,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":298883,"name":"Hassan Albadawi","orcid":"0000-0001-5913-8571","position":1,"is_corresponding":false},{"id":298882,"name":"Zefu Zhang","orcid":"0000-0002-7916-6147","position":2,"is_corresponding":false},{"id":1233870,"name":"Erin H. Graf","orcid":"0000-0002-6014-4570","position":3,"is_corresponding":false},{"id":1140530,"name":"Pedro Reck dos Santos","orcid":"0000-0002-5497-3188","position":4,"is_corresponding":false},{"id":658023,"name":"Şeyda Gündüz","orcid":"0000-0002-6658-6345","position":5,"is_corresponding":false},{"id":298887,"name":"Rahmi Öklü","orcid":"0000-0003-4984-1778","position":6,"is_corresponding":false},{"id":1215900,"name":"Hyeongseop Keum","orcid":"0000-0001-6680-5838","position":0,"is_corresponding":true}],"reference_count":27,"raw_metadata":null,"created_at":"2026-07-19T01:59:20.861374Z","pmid":"38305472","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}