{"doi":"10.1002/adma.202307726","title":"Interface‐Stabilized Fiber Sensor for Real‐Time Monitoring of Amniotic Fluid During Pregnancy","abstract":"<jats:title>Abstract</jats:title><jats:p>Diseases in pregnancy endanger millions of fetuses worldwide every year. The onset of these diseases can be early warned by the dynamic abnormalities of biochemicals in amniotic fluid, thus requiring real‐time monitoring. However, when continuously penetrated by detection devices, the amnion is prone to loss of robustness and rupture, which is difficult to regenerate. Here, an interface‐stabilized fiber sensor is presented for real‐time monitoring of biochemical dynamics in amniotic fluid during pregnancy. The sensor is seamlessly integrated into the amnion through tissue adhesion, amniotic regeneration, and uniform stress distribution, posing no risk to the amniotic fluid environment. The sensor demonstrates a response performance of less than 0.3% fluctuation under complex dynamic conditions and an accuracy of more than 98% from the second to the third trimester. By applying it to early warning of diseases such as intrauterine hypoxia, intrauterine infection, and fetal growth restriction, fetal survival increases to 95% with timely intervention.</jats:p>","journal":"Advanced Materials","year":2024,"id":645062,"datarank":0.519860385419959,"base_score":3.4657359027997265,"endowment":3.4657359027997265,"self_citation_contribution":0.519860385419959,"citation_network_contribution":0.0,"self_endowment_contribution":0.519860385419959,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":31,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":590435,"name":"Dan Li","orcid":"0000-0002-5586-4055","position":1,"is_corresponding":false},{"id":439193,"name":"Jiang Lu","orcid":null,"position":2,"is_corresponding":false},{"id":1679438,"name":"Kuangyi Zou","orcid":null,"position":3,"is_corresponding":false},{"id":297717,"name":"Lie Wang","orcid":"0000-0002-9406-5168","position":4,"is_corresponding":false},{"id":1679439,"name":"Yiding Jiao","orcid":null,"position":5,"is_corresponding":false},{"id":690618,"name":"Maosen Wang","orcid":"0000-0002-6302-0266","position":6,"is_corresponding":false},{"id":443690,"name":"Rui Gao","orcid":"0000-0003-1055-2936","position":7,"is_corresponding":false},{"id":875978,"name":"Jie Song","orcid":"0000-0002-4711-6014","position":8,"is_corresponding":false},{"id":1327723,"name":"Yiran Li","orcid":"0000-0003-4285-2079","position":9,"is_corresponding":false},{"id":1679440,"name":"Fangyan Li","orcid":null,"position":10,"is_corresponding":false},{"id":1679441,"name":"Jianjian Ji","orcid":null,"position":11,"is_corresponding":false},{"id":709111,"name":"Jiacheng Wang","orcid":"0000-0003-4327-1508","position":12,"is_corresponding":false},{"id":1345315,"name":"Luhe Li","orcid":"0000-0002-0182-3952","position":13,"is_corresponding":false},{"id":306410,"name":"Tingting Ye","orcid":null,"position":14,"is_corresponding":false},{"id":1679442,"name":"Er He","orcid":null,"position":15,"is_corresponding":false},{"id":242218,"name":"Hao Chen","orcid":"0000-0002-8874-0673","position":16,"is_corresponding":false},{"id":1679443,"name":"Yuanzhen Wang","orcid":null,"position":17,"is_corresponding":false},{"id":1679444,"name":"Junye Ren","orcid":null,"position":18,"is_corresponding":false},{"id":1679445,"name":"Chenyu Bai","orcid":null,"position":19,"is_corresponding":false},{"id":555395,"name":"Shuo Yang","orcid":"0000-0002-7929-0244","position":20,"is_corresponding":false},{"id":439543,"name":"Ye Zhang","orcid":"0000-0002-7376-6547","position":21,"is_corresponding":false},{"id":1679437,"name":"Qianming Li","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Interface‐Stabilized Fiber Sensor for Real‐Time Monitoring of Amniotic Fluid During Pregnancy","abstract":"<jats:title>Abstract</jats:title><jats:p>Diseases in pregnancy endanger millions of fetuses worldwide every year. The onset of these diseases can be early warned by the dynamic abnormalities of biochemicals in amniotic fluid, thus requiring real‐time monitoring. However, when continuously penetrated by detection devices, the amnion is prone to loss of robustness and rupture, which is difficult to regenerate. Here, an interface‐stabilized fiber sensor is presented for real‐time monitoring of biochemical dynamics in amniotic fluid during pregnancy. The sensor is seamlessly integrated into the amnion through tissue adhesion, amniotic regeneration, and uniform stress distribution, posing no risk to the amniotic fluid environment. The sensor demonstrates a response performance of less than 0.3% fluctuation under complex dynamic conditions and an accuracy of more than 98% from the second to the third trimester. By applying it to early warning of diseases such as intrauterine hypoxia, intrauterine infection, and fetal growth restriction, fetal survival increases to 95% with timely intervention.</jats:p>","is_dataset_classified":null,"base_score":3.4657359027997265,"endowment":3.4657359027997265,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37775103","pmcid":null,"openalex_id":"https://openalex.org/W4387160106","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"22175086","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"22005137","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"22205098","title":null},{"funder_name":"Fundamental Research Funds for the Central Universities","grant_id":"021314380234","title":null},{"funder_name":"Jiangsu Postdoctoral Research Foundation","grant_id":"2021K007A","title":null},{"funder_name":"China Postdoctoral Science Foundation","grant_id":"2021M700067","title":null},{"funder_name":"National Postdoctoral Program for Innovative Talents","grant_id":"BX20200161","title":null},{"funder_name":"Natural Science Foundation of Jiangsu Province","grant_id":"BK20200321","title":null},{"funder_name":"Program for Innovative Talents and Entrepreneurs in Jiangsu","grant_id":"JSSCTD202138","title":null}],"total_grants":9,"fwci":5.3303,"citation_percentile":0.96907742,"influential_citations":0,"citation_trend":[{"year":2023,"count":1},{"year":2024,"count":11},{"year":2025,"count":13},{"year":2026,"count":6}],"oa_status":"bronze","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adma.202307726","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adma.202307726","host_type":"publisher"},{"url":"https://advanced.onlinelibrary.wiley.com/doi/pdf/10.1002/adma.202307726","host_type":"publisher"},{"url":"https://doi.org/10.1002/adma.202307726","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/37775103","host_type":"repository"}],"fields_of_study":["Preterm Birth and Chorioamnionitis","Neonatal Respiratory Health Research","Pregnancy and preeclampsia studies","Pregnancy","Female","Humans","Amniotic Fluid","Amnion"],"mesh_terms":["Amnion","Amniotic Fluid","Female","Humans","Pregnancy"],"keywords":["Amniotic fluid","Amnion","Pregnancy","Biomedical engineering","Materials science","Fetus","Andrology","Obstetrics","Hypoxia (environmental)","Medicine","Biology","Chemistry","Real-time monitoring","Early warning","Fiber Sensor","Restorative Gel","Tissue-device Interface"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T02:45:40.273872Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}