{"doi":"10.1002/adma.202301493","title":"Tenascin‐C Activation of Lung Fibroblasts in a 3D Synthetic Lung Extracellular Matrix Mimic","abstract":"The lung extracellular matrix (ECM) maintains the structural integrity of the tissue and regulates the phenotype and functions of resident fibroblasts. Lung-metastatic breast cancer alters these cell-ECM interactions, promoting fibroblast activation. There is a need for bio-instructive ECM models that match the ECM composition and biomechanics of the lung to study these cell-matrix interactions in vitro. Here, a synthetic, bioactive hydrogel is synthesized that mimics the native lung modulus and includes a representative distribution of the most abundant ECM peptide motifs responsible for integrin-binding and matrix metalloproteinase (MMP)-mediated degradation in the lung, which enables quiescent culture of human lung fibroblasts (HLFs). Stimulation with transforming growth factor β1 (TGF-β1), metastatic breast cancer conditioned media (CM), or tenascin-C-derived integrin-binding peptide activated hydrogel-encapsulated HLFs demonstrates multiple environmental methods to activate HLFs in a lung ECM-mimicking hydrogel. This lung hydrogel platform is a tunable, synthetic approach to studying the independent and combinatorial effects of ECM in regulating fibroblast quiescence and activation.","journal":"Advanced Materials","year":2023,"id":359416,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9506,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":910344,"name":"Carey E. Dougan","orcid":"0000-0002-2165-771X","position":1,"is_corresponding":false},{"id":1110364,"name":"Samar Mahmoud","orcid":null,"position":2,"is_corresponding":false},{"id":1110365,"name":"Alara Kilic","orcid":null,"position":3,"is_corresponding":false},{"id":1110366,"name":"Alexi Panagiotou","orcid":null,"position":4,"is_corresponding":false},{"id":860996,"name":"Nathan Richbourg","orcid":"0000-0002-5091-3321","position":5,"is_corresponding":false},{"id":1110025,"name":"Ninette Irakoze","orcid":"0000-0001-8323-6745","position":6,"is_corresponding":false},{"id":299448,"name":"Shelly R. Peyton","orcid":"0000-0002-7364-8727","position":7,"is_corresponding":false},{"id":1009688,"name":"Aritra Nath Kundu","orcid":"0000-0001-5200-2153","position":0,"is_corresponding":true}],"reference_count":81,"raw_metadata":null,"created_at":"2026-07-19T01:13:52.889556Z","pmid":"37227134","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}