{"doi":"10.1002/adma.202210579","title":"Engineered Extracellular Vesicles Derived from Dermal Fibroblasts Attenuate Inflammation in a Murine Model of Acute Lung Injury","abstract":"Acute respiratory distress syndrome (ARDS) represents a significant burden to the healthcare system, with ≈200 000 cases diagnosed annually in the USA. ARDS patients suffer from severe refractory hypoxemia, alveolar-capillary barrier dysfunction, impaired surfactant function, and abnormal upregulation of inflammatory pathways that lead to intensive care unit admission, prolonged hospitalization, and increased disability-adjusted life years. Currently, there is no cure or FDA-approved therapy for ARDS. This work describes the implementation of engineered extracellular vesicle (eEV)-based nanocarriers for targeted nonviral delivery of anti-inflammatory payloads to the inflamed/injured lung. The results show the ability of surfactant protein A (SPA)-functionalized IL-4- and IL-10-loaded eEVs to promote intrapulmonary retention and reduce inflammation, both in vitro and in vivo. Significant attenuation is observed in tissue damage, proinflammatory cytokine secretion, macrophage activation, influx of protein-rich fluid, and neutrophil infiltration into the alveolar space as early as 6 h post-eEVs treatment. Additionally, metabolomics analyses show that eEV treatment causes significant changes in the metabolic profile of inflamed lungs, driving the secretion of key anti-inflammatory metabolites. Altogether, these results establish the potential of eEVs derived from dermal fibroblasts to reduce inflammation, tissue damage, and the prevalence/progression of injury during ARDS via nonviral delivery of anti-inflammatory genes/transcripts.","journal":"Advanced Materials","year":2023,"id":317370,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":79,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9511,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":661916,"name":"María A. Rincon‐Benavides","orcid":"0000-0001-6034-791X","position":1,"is_corresponding":false},{"id":907029,"name":"Tatiana Z. Cuellar‐Gaviria","orcid":"0000-0002-0822-4784","position":2,"is_corresponding":false},{"id":724420,"name":"Julian Aldana","orcid":"0000-0001-6378-1201","position":3,"is_corresponding":false},{"id":1022741,"name":"Gabriela Vásquez Martínez","orcid":"0000-0003-3239-3737","position":4,"is_corresponding":false},{"id":661918,"name":"Lilibeth Ortega‐Pineda","orcid":"0000-0001-9066-6719","position":5,"is_corresponding":false},{"id":1023504,"name":"Devleena Das","orcid":null,"position":6,"is_corresponding":false},{"id":661920,"name":"Daniel Dodd","orcid":"0000-0003-4095-053X","position":7,"is_corresponding":false},{"id":1023505,"name":"Charles A. Spencer","orcid":null,"position":8,"is_corresponding":false},{"id":465372,"name":"Binbin Deng","orcid":"0000-0002-4058-0738","position":9,"is_corresponding":false},{"id":94346,"name":"David W. McComb","orcid":"0000-0003-3763-9652","position":10,"is_corresponding":false},{"id":495261,"name":"Joshua A. Englert","orcid":"0000-0002-1257-2239","position":11,"is_corresponding":false},{"id":418701,"name":"Samir N. Ghadiali","orcid":"0000-0002-6845-774X","position":12,"is_corresponding":false},{"id":371821,"name":"Diana Zepeda‐Orozco","orcid":"0000-0003-0671-4453","position":13,"is_corresponding":false},{"id":401659,"name":"Loren E. Wold","orcid":"0000-0001-8155-0204","position":14,"is_corresponding":false},{"id":418702,"name":"Daniel Gallego‐Perez","orcid":"0000-0002-6263-3191","position":15,"is_corresponding":false},{"id":325828,"name":"Natalia Higuita‐Castro","orcid":"0000-0002-3297-6281","position":16,"is_corresponding":false},{"id":325829,"name":"Ana I. Salazar‐Puerta","orcid":"0000-0003-4954-6226","position":0,"is_corresponding":true}],"reference_count":132,"raw_metadata":null,"created_at":"2026-07-19T01:06:50.336418Z","pmid":"37119468","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}