{"doi":"10.1002/adma.202110340","title":"Submolecular Ligand Size and Spacing for Cell Adhesion","abstract":"Cell adhesion occurs when integrin recognizes and binds to Arg-Gly-Asp (RGD) ligands present in fibronectin. In this work, submolecular ligand size and spacing are tuned via template-mediated in situ growth of nanoparticles for dynamic macrophage modulation. To tune liganded gold nanoparticle (GNP) size and spacing from 3 to 20 nm, in situ localized assemblies of GNP arrays on nanomagnetite templates are engineered. 3 nm-spaced ligands stimulate the binding of integrin, which mediates macrophage-adhesion-assisted pro-regenerative polarization as compared to 20 nm-spaced ligands, which can be dynamically anchored to the substrate for stabilizing integrin binding and facilitating dynamic macrophage adhesion. Increasing the ligand size from 7 to 20 nm only slightly promotes macrophage adhesion, not observed with 13 nm-sized ligands. Increasing the ligand spacing from 3 to 17 nm significantly hinders macrophage adhesion that induces inflammatory polarization. Submolecular tuning of ligand spacing can dominantly modulate host macrophages.","journal":"Advanced Materials","year":2022,"id":246224,"datarank":0.5606504427425053,"base_score":3.7376696182833684,"endowment":3.7376696182833684,"self_citation_contribution":0.5606504427425053,"citation_network_contribution":0.0,"self_endowment_contribution":0.5606504427425053,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":41,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9567,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":882050,"name":"Thomas Myeongseok Koo","orcid":"0000-0001-7922-8865","position":2,"is_corresponding":false},{"id":853035,"name":"Ramar Thangam","orcid":"0000-0002-6209-7149","position":3,"is_corresponding":false},{"id":882051,"name":"Myeongsoo Kim","orcid":"0000-0003-3420-6317","position":4,"is_corresponding":false},{"id":882052,"name":"Woo Young Jang","orcid":"0000-0003-1775-7715","position":5,"is_corresponding":false},{"id":882053,"name":"Nayeon Kang","orcid":"0009-0003-3805-6675","position":6,"is_corresponding":false},{"id":882054,"name":"Sunhong Min","orcid":"0000-0001-9897-146X","position":7,"is_corresponding":false},{"id":882055,"name":"Seong Yeol Kim","orcid":"0000-0002-7195-1861","position":8,"is_corresponding":false},{"id":309011,"name":"Letao Yang","orcid":"0000-0002-0572-9787","position":9,"is_corresponding":false},{"id":882056,"name":"Hyunsik Hong","orcid":"0000-0003-0823-3119","position":10,"is_corresponding":false},{"id":882057,"name":"Hee Joon Jung","orcid":"0000-0001-7963-0897","position":11,"is_corresponding":false},{"id":882782,"name":"Eui Kwan Koh","orcid":null,"position":12,"is_corresponding":false},{"id":853033,"name":"Kapil D. 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