{"doi":"10.1002/adma.202002611","title":"Bioactive‐Tissue‐Derived Nanocomposite Hydrogel for Permanent Arterial Embolization and Enhanced Vascular Healing","abstract":"Transcatheter embolization is a minimally invasive procedure that uses embolic agents to intentionally block diseased or injured blood vessels for therapeutic purposes. Embolic agents in clinical practice are limited by recanalization, risk of non-target embolization, failure in coagulopathic patients, high cost, and toxicity. Here, a decellularized cardiac extracellular matrix (ECM)-based nanocomposite hydrogel is developed to provide superior mechanical stability, catheter injectability, retrievability, antibacterial properties, and biological activity to prevent recanalization. The embolic efficacy of the shear-thinning ECM-based hydrogel is shown in a porcine survival model of embolization in the iliac artery and the renal artery. The ECM-based hydrogel promotes arterial vessel wall remodeling and a fibroinflammatory response while undergoing significant biodegradation such that only 25% of the embolic material remains at 14 days. With its unprecedented proregenerative, antibacterial properties coupled with favorable mechanical properties, and its superior performance in anticoagulated blood, the ECM-based hydrogel has the potential to be a next-generation biofunctional embolic agent that can successfully treat a wide range of vascular diseases.","journal":"Advanced Materials","year":2020,"id":57303,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":79,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9514,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":298881,"name":"İzzet Altun","orcid":"0000-0001-6497-9017","position":1,"is_corresponding":false},{"id":298882,"name":"Zefu Zhang","orcid":"0000-0002-7916-6147","position":2,"is_corresponding":false},{"id":298883,"name":"Hassan Albadawi","orcid":"0000-0001-5913-8571","position":3,"is_corresponding":false},{"id":298884,"name":"Marcela Salomao","orcid":"0000-0002-3631-2407","position":4,"is_corresponding":false},{"id":298885,"name":"Joseph L. Mayer","orcid":"0009-0009-1986-9391","position":5,"is_corresponding":false},{"id":298886,"name":"L. P. Madhubhani P. Hemachandra","orcid":"0000-0001-7756-6190","position":6,"is_corresponding":false},{"id":300281,"name":"Suliman Rehman","orcid":null,"position":7,"is_corresponding":false},{"id":298887,"name":"Rahmi Öklü","orcid":"0000-0003-4984-1778","position":8,"is_corresponding":false},{"id":298880,"name":"Jingjie Hu","orcid":"0000-0002-3052-9496","position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":null,"created_at":"2026-07-18T21:06:31.136481Z","pmid":"32578337","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}