{"doi":"10.1002/adhm.202501529","title":"In Vivo Accumulation of Regulatory T Cells Using Eliglustat‐Loaded Cryogels","abstract":"Abstract Regulatory T cells (T regs ) maintain immune homeostasis and their adoptive transfer is being widely explored to mitigate inflammatory and autoimmune conditions. Here a biomaterial is developed to accumulate T regs at a specific anatomic location to bypass the need for ex vivo T reg isolation and adoptive transfer. It is first shown that eliglustat, an FDA‐approved inhibitor of UDP‐glucose ceramide glucosyltransferase, promotes T regs from both naïve and activated CD4 + T cells in vitro. Click‐crosslinked cryogels fabricated from alginate and collagen allow for a sustained release of CXCL10 or CXCL11, and when injected in subcutaneous tissues led to the enrichment of effector and memory T cells to the scaffolds. Loading eliglustat into these cryogels significantly enhances the local accumulation of T regs in vivo. These findings demonstrate that eliglustat‐loaded cryogels offer a simple yet effective biomaterial strategy to boost T reg directly in vivo, potentially providing a targeted method to treat various inflammatory and autoimmune diseases.","journal":"Advanced Healthcare Materials","year":2025,"id":544828,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9508,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1212428,"name":"Giovanni Bovone","orcid":"0000-0002-8508-0737","position":1,"is_corresponding":false},{"id":351127,"name":"Wei‐Hung Jung","orcid":"0000-0003-4342-4105","position":2,"is_corresponding":false},{"id":640173,"name":"Junzhe Lou","orcid":"0000-0002-3034-2445","position":3,"is_corresponding":false},{"id":1435715,"name":"Hugh Hankenson","orcid":null,"position":4,"is_corresponding":false},{"id":1036013,"name":"Mason T. Dacus","orcid":"0000-0002-2192-5382","position":5,"is_corresponding":false},{"id":997075,"name":"Yoav Binenbaum","orcid":"0000-0001-9901-7782","position":6,"is_corresponding":false},{"id":843852,"name":"Kwasi Adu‐Berchie","orcid":"0000-0002-1959-6794","position":7,"is_corresponding":false},{"id":461173,"name":"Alexander Stafford","orcid":"0000-0003-4739-8346","position":8,"is_corresponding":false},{"id":252880,"name":"Miguel C. Sobral","orcid":null,"position":9,"is_corresponding":false},{"id":421548,"name":"Benjamin R. Freedman","orcid":"0000-0001-9406-773X","position":10,"is_corresponding":false},{"id":1120868,"name":"Einat B. Vitner","orcid":"0000-0001-8578-8551","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":null,"created_at":"2026-07-19T02:53:17.418915Z","pmid":"40525671","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}