{"doi":"10.1002/adhm.202404189","title":"Hydrogel Adhesive Integrated‐Microstructured Electrodes for Cuff‐Free, Less‐Invasive, and Stable Interface for Vagus Nerve Stimulation","abstract":"Vagus nerve stimulation (VNS) is a recognized treatment for neurological disorders, yet the surgical procedure carries significant risks. During the process of isolating or cuffing the vagus nerve, there is a danger of damaging the nerve itself or the adjacent carotid artery or jugular vein. To minimize this risk, here we introduce a novel hydrogel adhesive-integrated and stretchable microdevice that provides a less invasive, cuff-free option for interfacing with the vagus nerve. The device features a novel hydrogel adhesive formulation that enables crosslinking on biological tissue. The inclusion of kirigami structures within the thin-film microdevice creates space for uniform hydrogel-to-epineurium contact while accommodating the stiffness changes of the hydrogel upon hydration. Using a rodent model, we demonstrate a robust device adhesion on a partially exposed vagus nerve in physiological fluid even without the vagus nerve isolation and cuffing process. Our device elicted stable and clear evoked compound action potential (~1500 µV peak-to-peak) in C-fibers with a current amplitude of 0.4 mA. We believe this innovative platform provides a novel, less-risky approach to interface with fragile nerve and vascular structures during VNS implantation.","journal":"Advanced Healthcare Materials","year":2025,"id":518157,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9523,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":827120,"name":"Jongcheon Lim","orcid":"0000-0003-2319-0727","position":1,"is_corresponding":false},{"id":732219,"name":"Carl Russell","orcid":"0009-0004-2451-2120","position":2,"is_corresponding":false},{"id":1385584,"name":"Pi-Hsin Chen","orcid":null,"position":3,"is_corresponding":false},{"id":1385585,"name":"Deniz Eksioglu","orcid":null,"position":4,"is_corresponding":false},{"id":1205569,"name":"Seokkyoon Hong","orcid":"0009-0007-6540-0389","position":5,"is_corresponding":false},{"id":1385586,"name":"Juan C. Mesa","orcid":null,"position":6,"is_corresponding":false},{"id":411820,"name":"Matthew Ward","orcid":"0000-0003-3214-4087","position":7,"is_corresponding":false},{"id":257741,"name":"Chi Hwan Lee","orcid":"0000-0002-4868-7054","position":8,"is_corresponding":false},{"id":417637,"name":"Hyowon Lee","orcid":"0000-0001-7628-1441","position":9,"is_corresponding":false},{"id":1385117,"name":"Jae Young Park","orcid":"0000-0003-3768-6889","position":0,"is_corresponding":true}],"reference_count":26,"raw_metadata":null,"created_at":"2026-07-19T02:49:04.756302Z","pmid":"40171796","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}