{"doi":"10.1002/adhm.202401444","title":"Anti‐Cytokine Active Immunotherapy Based on Supramolecular Peptides for Alleviating IL‐1β‐Mediated Inflammation","abstract":"IL-1β is a principal proinflammatory cytokine underlying multiple local and systemic chronic inflammatory conditions including psoriasis, rheumatoid arthritis, inflammatory bowel disease, and type 2 diabetes. Passive immunotherapies and biologic drugs targeting IL-1β, while offering significant clinical benefit, nevertheless have limitations such as significant non-response rates, induction of anti-drug antibodies, and high costs. Here, an active immunotherapy raising antibody responses against IL-1β employing self-assembling peptide nanofibers is described. The nanofibers contain defined quantities of B-cell epitopes from IL-1β and exogenous T helper epitopes and employ the Q11 self-assembling peptide platform. Without adjuvant, the nanofibers raised durable anti-IL-1β antibody responses that inhibit IL-1β activity in vitro and in vivo. In a mouse model of imiquimod-induced psoriasis, prophylactic immunizations with the nanofibers diminished symptoms of epidermal thickening. This therapeutic effect is associated with biasing the immune response toward an anti-inflammatory IgG1/Th2 phenotype and a lowered expression of proinflammatory genes in the skin. Further, anti-IL-1β nanofibers induced therapeutic immunosuppressive CD62L+ Treg cells. This technology represents a potential alternative for passive immunotherapies and other biologics for treating chronic inflammatory conditions.","journal":"Advanced Healthcare Materials","year":2024,"id":440927,"datarank":0.3950205689562558,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.04963280500714888,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.04963280500714888,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":8,"citers_with_citation_signal":5,"citers_with_endowment":5,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9546,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":352885,"name":"Yaoying Wu","orcid":"0000-0003-0570-2493","position":1,"is_corresponding":false},{"id":1253377,"name":"Christopher Z. Lloyd","orcid":null,"position":2,"is_corresponding":false},{"id":324733,"name":"Nalini Mehta","orcid":null,"position":3,"is_corresponding":false},{"id":290799,"name":"Yining Liu","orcid":"0009-0006-4253-0546","position":4,"is_corresponding":false},{"id":1058196,"name":"Mia E. Woodruff","orcid":"0009-0004-2719-2791","position":5,"is_corresponding":false},{"id":227278,"name":"Tatiana Segura","orcid":"0000-0003-1569-8686","position":6,"is_corresponding":false},{"id":240904,"name":"Joel H. Collier","orcid":"0000-0003-3536-4827","position":7,"is_corresponding":false},{"id":437673,"name":"Shamitha Shetty","orcid":"0000-0001-8771-5225","position":0,"is_corresponding":true}],"reference_count":66,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:01:01.842286Z","pmid":"39113323","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}