{"doi":"10.1002/adhm.202303709","title":"Antimicrobial Peptide‐ and Dentin Matrix‐Functionalized Hydrogel for Vital Pulp Therapy via Synergistic Bacteriostasis, Immunomodulation, and Dentinogenesis","abstract":"The preservation of vital pulps is crucial for maintaining the physiological functions of teeth; however, vital pulp therapy (VPT) of pulpitis teeth remains a substantial challenge due to uncontrolled infection, excessive inflammation, and limited regenerative potential. Current pulp capping agents have restricted effects in the infectious and inflammatory microenvironment. To address this, a multifunctional hydrogel (TGH/DM) with antibacterial, immunomodulatory, and mineralization-promoting effects is designed. The antimicrobial peptide (AMP) and demineralized dentin matrix are incorporated into the hydrogel, achieving sustainable delivery of AMP and a cocktail of growth factors. In vitro results show that TGH/DM could kill endodontic microbiota, ameliorate inflammatory responses of human dental pulp stem cells (hDPSCs), and prompt odontogenic differentiation of inflammatory hDPSCs via activation of peroxisome proliferator-activated receptor gamma. In vivo results suggest that TGH/DM is capable of inducing M2 phenotype transformation of macrophages in mice and fostering the regeneration of the dentin-pulp complex in inflamed pulps of beagle dogs. Overall, this study first proposes the synergistic regulation of AMP and tissue-specific extracellular matrix for the treatment of pulpitis, and the advanced hydrogel provides a facile and effective way for VPT.","journal":"Advanced Healthcare Materials","year":2024,"id":420586,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":33,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9547,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1212052,"name":"Wentao Jiang","orcid":"0000-0002-1779-0438","position":1,"is_corresponding":false},{"id":1212053,"name":"Hui Liu","orcid":"0009-0005-9611-273X","position":2,"is_corresponding":false},{"id":1212054,"name":"Lingling Chen","orcid":"0000-0002-4017-1037","position":3,"is_corresponding":false},{"id":1212714,"name":"Chengkai Xuan","orcid":null,"position":4,"is_corresponding":false},{"id":1212055,"name":"Zhenxing Wang","orcid":"0000-0002-2436-0372","position":5,"is_corresponding":false},{"id":1212056,"name":"Xuetao Shi","orcid":"0000-0003-3896-5097","position":6,"is_corresponding":false},{"id":593524,"name":"Zhengmei Lin","orcid":"0000-0003-1586-3741","position":7,"is_corresponding":false},{"id":1212715,"name":"Xianling Gao","orcid":null,"position":8,"is_corresponding":false},{"id":1212051,"name":"Zhuo Xie","orcid":"0009-0006-7021-5818","position":0,"is_corresponding":true}],"reference_count":78,"raw_metadata":null,"created_at":"2026-07-19T01:57:31.041511Z","pmid":"38431770","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}