{"doi":"10.1002/adhm.202303511","title":"Wearable Microneedle Patch for Colorimetric Detection of Multiple Signature Biomarkers in vivo Toward Diabetic Diagnosis","abstract":"<jats:title>Abstract</jats:title><jats:p>Type 2 diabetes is rapidly emerging as a global public health problem. While blood glucose monitoring has been the primary method of managing diabetes for decades, the increasing global prevalence of the disease suggests that there might be a need to identify additional biomarkers for a more precise early diagnosis. Herein, a microneedle patch based wearable sensor is developed for the purpose of diabetic diagnosis. Utilizing methacrylic acid modified gelatin and polyvinyl alcohol in the fabrication of microneedles has improved their mechanical properties for skin penetration and increased swelling capacity for interstitial fluid extraction, thanks to the double crosslinking mechanism. The fabricated microneedles are further integrated with test paper functionalized with enzyme and dye molecules to detect multiple signature biomarkers of diabetes in vivo through a colorimetric reaction. Such a wearable microneedle patch  holds significant promise for the real‐time monitoring of various biomarkers related to chronic diseases and aging.</jats:p>","journal":"Advanced Healthcare Materials","year":2024,"id":633328,"datarank":0.5983476069846413,"base_score":3.9889840465642745,"endowment":3.9889840465642745,"self_citation_contribution":0.5983476069846413,"citation_network_contribution":0.0,"self_endowment_contribution":0.5983476069846413,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":53,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1179258,"name":"Sheng Lu","orcid":"0000-0003-3115-7599","position":1,"is_corresponding":false},{"id":834515,"name":"Duo Zhang","orcid":"0009-0000-3350-5716","position":2,"is_corresponding":false},{"id":636092,"name":"Guanyu Wang","orcid":"0000-0002-6792-3091","position":3,"is_corresponding":false},{"id":1641936,"name":"Xiaolin Cui","orcid":"0000-0001-5118-0169","position":4,"is_corresponding":false},{"id":413568,"name":"Guozhen Liu","orcid":"0000-0002-0556-6404","position":5,"is_corresponding":false},{"id":1641935,"name":"Ziting Bao","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Wearable Microneedle Patch for Colorimetric Detection of Multiple Signature Biomarkers in vivo Toward Diabetic Diagnosis","abstract":"<jats:title>Abstract</jats:title><jats:p>Type 2 diabetes is rapidly emerging as a global public health problem. While blood glucose monitoring has been the primary method of managing diabetes for decades, the increasing global prevalence of the disease suggests that there might be a need to identify additional biomarkers for a more precise early diagnosis. Herein, a microneedle patch based wearable sensor is developed for the purpose of diabetic diagnosis. Utilizing methacrylic acid modified gelatin and polyvinyl alcohol in the fabrication of microneedles has improved their mechanical properties for skin penetration and increased swelling capacity for interstitial fluid extraction, thanks to the double crosslinking mechanism. The fabricated microneedles are further integrated with test paper functionalized with enzyme and dye molecules to detect multiple signature biomarkers of diabetes in vivo through a colorimetric reaction. Such a wearable microneedle patch  holds significant promise for the real‐time monitoring of various biomarkers related to chronic diseases and aging.</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38353398","pmcid":null,"openalex_id":null,"authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"22174121","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"22211530067","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"T2250710180","title":null},{"funder_name":"Chinese University of Hong Kong, Shenzhen","grant_id":"UDF01002012","title":null},{"funder_name":"Chinese University of Hong Kong, Shenzhen","grant_id":"UDF01002535","title":null},{"funder_name":"Guangdong Peral River Talent Program","grant_id":"2021CX02Y066","title":null},{"funder_name":"Chinese University of Hong Kong, Shenzhen startup funding","grant_id":"K10120220254","title":null},{"funder_name":"Ministry of Science and Technology of China International Young Scholar Grant","grant_id":"QN2023032004L","title":null},{"funder_name":"Shenzhen Natural Science Foundation and Shenzhen-Hong Kong Cooperation Zone for Technology and Innovation","grant_id":"HZQB-KCZYB-2020056","title":null},{"funder_name":"CUHK(SZ)-The Second Affiliated Hospital Joint Fund","grant_id":"YXLH2205","title":null},{"funder_name":"2022 Natural Science Foundation of Guangdong Provincial Basic and Applied Basic Research Fund","grant_id":"","title":null},{"funder_name":"CUHK(SZ)-Boyalife Joint Laboratory Fund","grant_id":"","title":null},{"funder_name":"Shenzhen Bay Open Laboratory Fund 2021","grant_id":"","title":null}],"total_grants":13,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://advanced.onlinelibrary.wiley.com/doi/pdf/10.1002/adhm.202303511","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":["Animals","Humans","Mice","Diabetes Mellitus, Type 2","Polyvinyl Alcohol","Gelatin","Colorimetry","Needles","Biomarkers","Wearable Electronic Devices"],"keywords":["Type 2 diabetes","hydrogel","Microneedles","Wearable Biosensors","Colorimetric Reaction"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T11:51:20.310744Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}