{"doi":"10.1002/adhm.202302425","title":"Engineering Improved CAR T Cell Products with A Multi‐Cytokine Particle Platform for Hematologic and Solid Tumors","abstract":"Despite the remarkable clinical efficacy of chimeric antigen receptor (CAR) T cells in hematological malignancies, only a subset of patients achieves a durable complete response (dCR). DCR has been correlated with CAR T cell products enriched with T cells memory phenotypes. Therefore, reagents that consistently promote memory phenotypes during the manufacturing of CAR T cells have the potential to significantly improve clinical outcomes. A novel modular multi-cytokine particle (MCP) platform is developed that combines the signals necessary for activation, costimulation, and cytokine support into a single \"all-in-one\" stimulation reagent for CAR T cell manufacturing. This platform allows for the assembly and screening of compositionally diverse MCP libraries to identify formulations tailored to promote specific phenotypes with a high degree of flexibility. The approach is leveraged to identify unique MCP formulations that manufacture CAR T cell products from diffuse large B cell patients with increased proportions of memory-like phenotypes MCP-manufactured CAR T cells demonstrate superior anti-tumor efficacy in mouse models of lymphoma and ovarian cancer through enhanced persistence. These findings serve as a proof-of-principle of the powerful utility of the MCP platform to identify \"all-in-one\" stimulation reagents that can improve the effectiveness of cell therapy products through optimal manufacturing.","journal":"Advanced Healthcare Materials","year":2024,"id":455202,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9474,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":683308,"name":"Biaggio Uricoli","orcid":"0000-0001-5106-7107","position":1,"is_corresponding":false},{"id":1223204,"name":"Ruby Freeman","orcid":null,"position":2,"is_corresponding":false},{"id":1279453,"name":"AKM Nawshad Hossian","orcid":null,"position":3,"is_corresponding":false},{"id":1105108,"name":"Zhulin He","orcid":"0000-0002-5852-8065","position":4,"is_corresponding":false},{"id":1279454,"name":"Ji Young L. Anderson","orcid":null,"position":5,"is_corresponding":false},{"id":1279062,"name":"Milla-Riina Neffling","orcid":"0009-0000-3360-4335","position":6,"is_corresponding":false},{"id":1279455,"name":"Jonathan M. Legier","orcid":null,"position":7,"is_corresponding":false},{"id":1279456,"name":"Dejah Blake","orcid":null,"position":8,"is_corresponding":false},{"id":700291,"name":"Deon B. Doxie","orcid":"0000-0002-5383-0441","position":9,"is_corresponding":false},{"id":972048,"name":"Remya Nair","orcid":"0000-0002-6898-3424","position":10,"is_corresponding":false},{"id":680215,"name":"Jean L. Koff","orcid":"0000-0003-4414-0489","position":11,"is_corresponding":false},{"id":318424,"name":"Kavita M. Dhodapkar","orcid":"0000-0003-0587-4172","position":12,"is_corresponding":false},{"id":275300,"name":"Mala Shanmugam","orcid":"0000-0002-4415-8083","position":13,"is_corresponding":false},{"id":332513,"name":"Erik C. Dreaden","orcid":"0000-0002-4954-8443","position":14,"is_corresponding":false},{"id":254269,"name":"Sarwish Rafiq","orcid":"0000-0002-9295-3065","position":15,"is_corresponding":false},{"id":264525,"name":"Heather Lin","orcid":"0000-0002-5631-4856","position":0,"is_corresponding":true}],"reference_count":68,"raw_metadata":null,"created_at":"2026-07-19T02:03:17.458329Z","pmid":"38245855","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}