{"doi":"10.1002/adhm.202001894","title":"Delivery of Anti‐microRNA‐712 to Inflamed Endothelial Cells Using Poly(<i>β</i>‐amino ester) Nanoparticles Conjugated with VCAM‐1 Targeting Peptide","abstract":"Endothelial cells (ECs) are an important target for therapy in a wide range of diseases, most notably atherosclerosis. Developing efficient nanoparticle (NP) systems that deliver RNA interference (RNAi) drugs specifically to dysfunctional ECs in vivo to modulate their gene expression remains a challenge. To date, several lipid-based NPs are developed and shown to deliver RNAi to ECs, but few of them are optimized to specifically target dysfunctional endothelium. Here, a novel, targeted poly(β-amino ester) (pBAE) NP is demonstrated. This pBAE NP is conjugated with VHPK peptides that target vascular cell adhesion molecule 1 protein, overexpressed on inflamed EC membranes. To test this approach, the novel NPs are used to deliver anti-microRNA-712 (anti-miR-712) specifically to inflamed ECs both in vitro and in vivo, reducing the high expression of pro-atherogenic miR-712. A single administration of anti-miR-712 using the VHPK-conjugated-pBAE NPs in mice significantly reduce miR-712 expression, while preventing the loss of its target gene, tissue inhibitor of metalloproteinase 3 (TIMP3) in inflamed endothelium. miR-712 and TIMP3 expression are unchanged in non-inflamed endothelium. This novel, targeted-delivery platform may be used to deliver RNA therapeutics specifically to dysfunctional endothelium for the treatment of vascular disease.","journal":"Advanced Healthcare Materials","year":2021,"id":153475,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":68,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9584,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":652380,"name":"Ian A. Tamargo","orcid":null,"position":1,"is_corresponding":false},{"id":651108,"name":"Víctor Ramos","orcid":"0000-0002-2099-5557","position":2,"is_corresponding":false},{"id":240720,"name":"Sandeep Kumar","orcid":"0000-0003-3440-3628","position":3,"is_corresponding":false},{"id":240722,"name":"Dong Won Kang","orcid":"0000-0003-0144-6795","position":4,"is_corresponding":false},{"id":651109,"name":"Salvador Borrós","orcid":"0000-0002-4003-0381","position":5,"is_corresponding":false},{"id":240726,"name":"Hanjoong Jo","orcid":"0000-0003-1833-372X","position":6,"is_corresponding":false},{"id":651107,"name":"Pere Dosta","orcid":"0000-0002-4407-1420","position":0,"is_corresponding":true}],"reference_count":60,"raw_metadata":null,"created_at":"2026-07-18T23:43:44.759273Z","pmid":"33448151","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}