{"doi":"10.1002/adhm.202000527","title":"Biodegradable <i>β</i>‐Cyclodextrin Conjugated Gelatin Methacryloyl Microneedle for Delivery of Water‐Insoluble Drug","abstract":"Transdermal delivery of water-insoluble drugs via hydrogel-based microneedle (MN) arrays is crucial for improving their therapeutic efficacies. However, direct loading of water-insoluble drug into hydrophilic matrices remains challenging. Here, a biodegradable MN array patch that is fabricated from naturally derived polymer conjugates of gelatin methacryloyl and β-cyclodextrin (GelMA-β-CD) is reported. When curcumin, an unstable and water-insoluble anticancer drug, is loaded as a model drug, its stability and solubility are improved due to the formation of an inclusion complex. The polymer-drug complex GelMA-β-CD/CUR can be formulated into MN arrays with sufficient mechanical strength for skin penetration and tunable drug release profile. Anticancer efficacy of released curcumin is observed in three-dimensional B16F10 melanoma models. The GelMA-β-CD/CUR MN exhibits relatively higher therapeutic efficacy through more localized and deeper penetrated manner compared with a control nontransdermal patch. In vivo studies also verify biocompatibility and degradability of the GelMA-β-CD MN arrays patch.","journal":"Advanced Healthcare Materials","year":2020,"id":51682,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":150,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9399,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":258845,"name":"Zhimin Luo","orcid":"0000-0001-5071-4325","position":1,"is_corresponding":false},{"id":258846,"name":"Avijit Baidya","orcid":"0000-0001-5215-2856","position":2,"is_corresponding":false},{"id":241785,"name":"Han‐Jun Kim","orcid":"0000-0001-9238-7238","position":3,"is_corresponding":false},{"id":244846,"name":"Canran Wang","orcid":"0000-0003-3297-9041","position":4,"is_corresponding":false},{"id":244844,"name":"Xing Jiang","orcid":"0000-0002-3096-2716","position":5,"is_corresponding":false},{"id":244843,"name":"Moyuan Qu","orcid":"0009-0002-7481-3496","position":6,"is_corresponding":false},{"id":244841,"name":"Jixiang Zhu","orcid":"0000-0002-7898-7672","position":7,"is_corresponding":false},{"id":244845,"name":"Li Ren","orcid":"0000-0002-1989-9488","position":8,"is_corresponding":false},{"id":258847,"name":"Fereshteh Vajhadin","orcid":"0000-0003-2361-8981","position":9,"is_corresponding":false},{"id":242298,"name":"Peyton Tebon","orcid":"0000-0002-4673-1760","position":10,"is_corresponding":false},{"id":261156,"name":"Ni‐Yuan Zhang","orcid":null,"position":11,"is_corresponding":false},{"id":241781,"name":"Yumeng Xue","orcid":"0000-0001-8831-9793","position":12,"is_corresponding":false},{"id":261157,"name":"Yudi Feng","orcid":null,"position":13,"is_corresponding":false},{"id":258848,"name":"Chengbin Xue","orcid":"0000-0003-1378-672X","position":14,"is_corresponding":false},{"id":258849,"name":"Yi Chen","orcid":"0000-0001-5329-4987","position":15,"is_corresponding":false},{"id":241783,"name":"KangJu Lee","orcid":"0000-0003-2166-0916","position":16,"is_corresponding":false},{"id":241786,"name":"Junmin Lee","orcid":"0000-0002-4414-7130","position":17,"is_corresponding":false},{"id":241774,"name":"Shiming Zhang","orcid":"0000-0002-9727-028X","position":18,"is_corresponding":false},{"id":258850,"name":"C. F. Xu","orcid":"0000-0001-8831-3607","position":19,"is_corresponding":false},{"id":230337,"name":"Nureddin Ashammakhi","orcid":"0000-0003-0181-6055","position":20,"is_corresponding":false},{"id":241790,"name":"Samad Ahadian","orcid":"0000-0002-6784-5716","position":21,"is_corresponding":false},{"id":241791,"name":"Mehmet R. Dokmeci","orcid":"0000-0003-2226-9441","position":22,"is_corresponding":false},{"id":238002,"name":"Zhen Gu","orcid":"0000-0003-2947-4456","position":23,"is_corresponding":false},{"id":241784,"name":"Wujin Sun","orcid":"0000-0002-3167-111X","position":24,"is_corresponding":false},{"id":230339,"name":"Ali Khademhosseini","orcid":"0000-0002-2692-1524","position":25,"is_corresponding":false},{"id":244842,"name":"Xingwu Zhou","orcid":"0000-0001-5977-2185","position":0,"is_corresponding":true}],"reference_count":60,"raw_metadata":null,"created_at":"2026-07-18T20:41:30.009880Z","pmid":"32364331","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}