{"doi":"10.1002/adhm.201901714","title":"Stimuli‐Responsive Delivery of Growth Factors for Tissue Engineering","abstract":"Growth factors (GFs) play a crucial role in directing stem cell behavior and transmitting information between different cell populations for tissue regeneration. However, their utility as therapeutics is limited by their short half-life within the physiological microenvironment and significant side effects caused by off-target effects or improper dosage. \"Smart\" materials that can not only sustain therapeutic delivery over a treatment period but also facilitate on-demand release upon activation are attracting significant interest in the field of GF delivery for tissue engineering. Three properties are essential in engineering these \"smart\" materials: 1) the cargo vehicle protects the encapsulated therapeutic; 2) release is targeted to the site of injury; 3) cargo release can be modulated by disease-specific stimuli. The aim of this review is to summarize the current research on stimuli-responsive materials as intelligent vehicles for controlled GF delivery; Five main subfields of tissue engineering are discussed: skin, bone and cartilage, muscle, blood vessel, and nerve. Challenges in achieving such \"smart\" materials and perspectives on future applications of stimuli-responsive GF delivery for tissue regeneration are also discussed.","journal":"Advanced Healthcare Materials","year":2020,"id":51000,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":171,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9449,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":244844,"name":"Xing Jiang","orcid":"0000-0002-3096-2716","position":1,"is_corresponding":false},{"id":244842,"name":"Xingwu Zhou","orcid":"0000-0001-5977-2185","position":2,"is_corresponding":false},{"id":244846,"name":"Canran Wang","orcid":"0000-0003-3297-9041","position":3,"is_corresponding":false},{"id":253540,"name":"Qingzhi Wu","orcid":"0000-0002-1381-7242","position":4,"is_corresponding":false},{"id":244845,"name":"Li Ren","orcid":"0000-0002-1989-9488","position":5,"is_corresponding":false},{"id":244841,"name":"Jixiang Zhu","orcid":"0000-0002-7898-7672","position":6,"is_corresponding":false},{"id":253541,"name":"Songsong Zhu","orcid":"0000-0001-7593-3663","position":7,"is_corresponding":false},{"id":242298,"name":"Peyton Tebon","orcid":"0000-0002-4673-1760","position":8,"is_corresponding":false},{"id":241784,"name":"Wujin Sun","orcid":"0000-0002-3167-111X","position":9,"is_corresponding":false},{"id":230339,"name":"Ali Khademhosseini","orcid":"0000-0002-2692-1524","position":10,"is_corresponding":false},{"id":244843,"name":"Moyuan Qu","orcid":"0009-0002-7481-3496","position":0,"is_corresponding":true}],"reference_count":176,"raw_metadata":null,"created_at":"2026-07-18T20:40:28.278215Z","pmid":"32125786","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}