{"doi":"10.1002/adhm.201801631","title":"3D Bioprinting of Functional Islets of Langerhans in an Alginate/Methylcellulose Hydrogel Blend","abstract":"<jats:title>Abstract</jats:title><jats:p>Transplantation of pancreatic islets is a promising strategy to alleviate the unstable blood‐glucose control that some patients with diabetes type 1 exhibit and has seen many advances over the years. Protection of transplanted islets from the immune system can be accomplished by encapsulation within a hydrogel, the most investigated of which is alginate. In this study, islet encapsulation is combined with 3D extrusion bioprinting, an additive manufacturing method which enables the fabrication of 3D structures with a precise geometry to produce macroporous hydrogel constructs with embedded islets. Using a plottable hydrogel blend consisting of clinically approved ultrapure alginate and methylcellulose (Alg/MC) enables encapsulating pancreatic islets in macroporous 3D hydrogel constructs of defined geometry while retaining their viability, morphology, and functionality. Diffusion of glucose and insulin in the Alg/MC hydrogel is comparable to diffusion in plain alginate; the embedded islets continuously produce insulin and glucagon throughout the observation and still react to glucose stimulation albeit to a lesser degree than control islets.</jats:p>","journal":"Advanced Healthcare Materials","year":2019,"id":639915,"datarank":0.7278045395879427,"base_score":4.852030263919617,"endowment":4.852030263919617,"self_citation_contribution":0.7278045395879427,"citation_network_contribution":0.0,"self_endowment_contribution":0.7278045395879427,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":127,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1662945,"name":"Kathleen Schütz","orcid":null,"position":1,"is_corresponding":false},{"id":1662946,"name":"Tilman Ahlfeld","orcid":null,"position":2,"is_corresponding":false},{"id":1662947,"name":"Susann Lehmann","orcid":null,"position":3,"is_corresponding":false},{"id":1662948,"name":"Anja Lode","orcid":null,"position":4,"is_corresponding":false},{"id":1662949,"name":"Barbara Ludwig","orcid":null,"position":5,"is_corresponding":false},{"id":617646,"name":"Michael Gelinsky","orcid":"0000-0001-9075-5121","position":6,"is_corresponding":false},{"id":1662944,"name":"Sarah Duin","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-08-07T04:26:30.224986Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}