{"doi":"10.1002/adfm.202423036","title":"Glucose‐Facilitated Nanomicelles Cross Peripheral Nerve Barriers to Achieve Drug Delivery to Nerves","abstract":"Abstract Injecting nerve‐blocking agents near peripheral nerves is a clinical option for treating post‐operative and chronic pain. However, the peripheral nerve barriers (PNBs) pose a physiological barrier that hinders the permeation of nerve‐blocking agents through PNBs, ultimately affecting their efficacy on neurons. Here, glucose‐modified nanomicelles (Glu‐NMs) are developed that are self‐assembled from glucose‐functionalized 3‐aminophenylboronic acid‐ polyethylene glycol‐ stearic acid polymer (GLU‐PBA‐PEG‐SA) and Pluronic P 123 . It is demonstrated that Glu‐NMs exhibit enhanced cellular uptake by perineurial cells and improved permeation through PNBs in rats, compared to unmodified nanomicelles (NMs). This enhancement is facilitated by carrier‐mediated transport through glucose transporters. A single injection of capsaicin‐loaded Glu‐NMs (CAP@Glu‐NMs) containing 1 mg of capsaicin at the sciatic nerves of rats resulted in nociceptive‐selective nerve blockade lasting for 48.0 ± 19.6 h, which is seven times longer than the duration achieved with an equivalent dose of plain capsaicin and twice as long as that of capsaicin‐loaded NMs (CAP@NMs). Furthermore, the CAP@Glu‐NMs significantly mitigate capsaicin‐associated side effects and result in benign local tissue reactions.","journal":"Advanced Functional Materials","year":2025,"id":518038,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9464,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1256798,"name":"Yuhao Cai","orcid":null,"position":1,"is_corresponding":false},{"id":1384990,"name":"Sumiran Kumar Gurung","orcid":"0000-0003-2374-2771","position":2,"is_corresponding":false},{"id":1384991,"name":"Shreyas S. Rao","orcid":"0000-0001-7649-0171","position":3,"is_corresponding":false},{"id":702404,"name":"Chao Zhao","orcid":"0000-0001-7192-7856","position":4,"is_corresponding":false},{"id":1384989,"name":"Xiaoyan Ma","orcid":"0000-0002-4592-4800","position":0,"is_corresponding":true}],"reference_count":56,"raw_metadata":null,"created_at":"2026-07-19T02:49:04.756302Z","pmid":"40881774","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}