{"doi":"10.1002/adfm.202100850","title":"Self‐Oxygenation of Tissues Orchestrates Full‐Thickness Vascularization of Living Implants","abstract":"Bioengineering of tissues and organs has the potential to generate functional replacement organs. However, achieving the full-thickness vascularization that is required for long-term survival of living implants has remained a grand challenge, especially for clinically sized implants. During the pre-vascular phase, implanted engineered tissues are forced to metabolically rely on the diffusion of nutrients from adjacent host-tissue, which for larger living implants results in anoxia, cell death, and ultimately implant failure. Here it is reported that this challenge can be addressed by engineering self-oxygenating tissues, which is achieved via the incorporation of hydrophobic oxygen-generating micromaterials into engineered tissues. Self-oxygenation of tissues transforms anoxic stresses into hypoxic stimulation in a homogenous and tissue size-independent manner. The in situ elevation of oxygen tension enables the sustained production of high quantities of angiogenic factors by implanted cells, which are offered a metabolically protected pro-angiogenic microenvironment. Numerical simulations predict that self-oxygenation of living tissues will effectively orchestrate rapid full-thickness vascularization of implanted tissues, which is empirically confirmed via in vivo experimentation. Self-oxygenation of tissues thus represents a novel, effective, and widely applicable strategy to enable the vascularization living implants, which is expected to advance organ transplantation and regenerative medicine applications.","journal":"Advanced Functional Materials","year":2021,"id":162924,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":44,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9547,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":317869,"name":"Shabir Hassan","orcid":"0000-0002-5822-9508","position":1,"is_corresponding":false},{"id":235451,"name":"Liliana Moreira Teixeira","orcid":"0000-0001-5039-8369","position":2,"is_corresponding":false},{"id":631032,"name":"Melvin Gurian","orcid":"0000-0001-5522-3875","position":3,"is_corresponding":false},{"id":681421,"name":"João F. Crispim","orcid":"0000-0001-6818-6401","position":4,"is_corresponding":false},{"id":681422,"name":"Varun Manhas","orcid":"0000-0002-8024-9994","position":5,"is_corresponding":false},{"id":681423,"name":"Aurélie Carlier","orcid":"0000-0002-2305-5667","position":6,"is_corresponding":false},{"id":681424,"name":"Hojae Bae","orcid":"0000-0003-3057-4999","position":7,"is_corresponding":false},{"id":681425,"name":"Liesbet Geris","orcid":"0000-0002-8180-1445","position":8,"is_corresponding":false},{"id":649841,"name":"Iman Noshadi","orcid":"0000-0002-0683-5426","position":9,"is_corresponding":false},{"id":241430,"name":"Su Ryon Shin","orcid":"0000-0003-0864-6482","position":10,"is_corresponding":false},{"id":310831,"name":"Jeroen Leijten","orcid":"0000-0002-8063-207X","position":11,"is_corresponding":false},{"id":226019,"name":"Ali Farzin","orcid":"0000-0002-7957-065X","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-18T23:45:17.971865Z","pmid":"34924912","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}