{"doi":"10.1002/adbi.202300633","title":"The Association Between C24:0/C16:0 Ceramide Ratio and Cardiorespiratory Fitness is Robust to Effect Modifications by Age and Sex","abstract":"Abstract Ceramides and cardiorespiratory (CR) fitness are both related to cardiovascular diseases. The associations of three blood plasma ceramides (C16:0, C22:0, and C24:0) with CR fitness in the population‐based Study of Health in Pomerania (SHIP‐START‐1; n = 1,102; mean age 50.3 years, 51.5% women) are investigated. In addition, subgroup analysis according to age (</≥54 years) and sex (female/male) is performed. Ceramides are quantified by liquid chromatography/mass spectrometry (LC/MS). CR fitness is assessed by a cardiopulmonary exercise test. Sex and age independent associations are found for higher levels of C24:0 and C24:0/C16:0 ratio with higher maximal oxygen consumption (VO 2 peak) kg −1 and oxygen consumption at the anaerobic threshold (VO 2 @AT 1 ) as well as for the relation of C24:0/C16:0 with maximum workload (Wattmax kg −1 ). In contrast, age/sex subgroup specific inverse associations with Wattmax kg −1 are found in women <54 years for C22:0, while a positive association in men ≥54 years. Higher levels of C24:0 are associated with higher Wattmax kg −1 , except for women <54 years, where no significant association can be found. The findings suggest that the use of single ceramides as cardiovascular biomarkers may be inferior, compared to ceramide ratio C24:0/C16:0. Therefore C24:0/C16:0 ratio may be a more suitable and robust cardiovascular biomarker and should be preferred over single ceramides.","journal":"Advanced Biology","year":2024,"id":448412,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9377,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":880055,"name":"Stephanie Zylla","orcid":"0000-0001-7417-4407","position":1,"is_corresponding":false},{"id":435717,"name":"Marcello Ricardo Paulista Markus","orcid":"0000-0002-6234-4955","position":2,"is_corresponding":false},{"id":268147,"name":"Ralf Ewert","orcid":"0000-0002-6746-9925","position":3,"is_corresponding":false},{"id":541029,"name":"Sven Gläser","orcid":"0000-0002-3971-5842","position":4,"is_corresponding":false},{"id":5359,"name":"Henry Völzke","orcid":"0000-0001-7003-399X","position":5,"is_corresponding":false},{"id":1267002,"name":"Diana Albrecht","orcid":"0000-0002-9495-2365","position":6,"is_corresponding":false},{"id":2346,"name":"Nele Friedrich","orcid":"0000-0002-1017-7622","position":7,"is_corresponding":false},{"id":2347,"name":"Matthias Nauck","orcid":"0000-0002-6678-7964","position":8,"is_corresponding":false},{"id":340225,"name":"Linda R. Peterson","orcid":"0000-0001-8766-4552","position":9,"is_corresponding":false},{"id":308930,"name":"Xuntian Jiang","orcid":"0000-0001-9048-7294","position":10,"is_corresponding":false},{"id":340224,"name":"Jean E. Schaffer","orcid":"0000-0002-4954-6659","position":11,"is_corresponding":false},{"id":55734,"name":"Stephan B. Felix","orcid":"0000-0002-0744-091X","position":12,"is_corresponding":false},{"id":21754,"name":"Marcus Dörr","orcid":"0000-0001-7471-475X","position":13,"is_corresponding":false},{"id":880054,"name":"Martin Bahls","orcid":"0000-0002-2016-5852","position":14,"is_corresponding":false},{"id":744409,"name":"Stefan Groß","orcid":"0000-0003-4121-7161","position":15,"is_corresponding":false},{"id":1267405,"name":"Jule Zatloukal","orcid":null,"position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":null,"created_at":"2026-07-19T02:02:08.018689Z","pmid":"38342586","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}