{"doi":"10.1002/acr2.11605","title":"Higher Odds of Adverse Cutaneous Reactions in Patients With Dermatomyositis Treated With Hydroxychloroquine Compared With Methotrexate","abstract":"OBJECTIVE: Hydroxychloroquine (HCQ) use for the treatment of dermatomyositis (DM) has been associated with adverse cutaneous reactions. We applied a new user, active comparator, retrospective design to assess differences in adverse cutaneous reactions or hospitalizations between HCQ and methotrexate (MTX) use among patients with DM. METHODS: We used a national network of data from insurance registries (TriNetX), enrolling patients with two International Classification of Diseases (ICD) codes for DM separated by 6 months or more who had a prescription for either (but not both) HCQ or MTX on or after DM diagnosis. Outcomes were adverse cutaneous reactions (ICD codes) or hospital admission (Current Procedural Terminology (CPT) codes) within 4 months from the prescription dispense date. Logistic regression was used to produce adjusted odds ratios (aORs) and 95% confidence intervals (CIs) comparing outcomes in the HCQ group (n = 1364) and the MTX group (n = 1400), adjusted for age at first DM diagnosis, year of birth, sex, and time from DM diagnosis to first prescription. RESULTS: Overall, we found no significant difference in odds of hospitalization in those taking HCQ (aOR 1.05; 95% CI: 0.79-1.39) compared with those on MTX. Patients with DM on HCQ had 30% higher odds of adverse cutaneous reaction diagnosis compared with patients on MTX (aOR 1.30; 95% CI: 1.02-1.59). Age at DM diagnosis was an effect modifier of this association, with higher odds of adverse cutaneous reaction among patients taking HCQ who were younger at diagnosis. CONCLUSION: Compared with MTX use, HCQ use, especially in younger patients, may result in higher odds of adverse cutaneous reactions.","journal":"ACR Open Rheumatology","year":2023,"id":377635,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9171,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1141292,"name":"Alison Nancy Hollis","orcid":"0000-0002-6849-1227","position":1,"is_corresponding":false},{"id":509635,"name":"Carolina Álvarez","orcid":"0000-0003-1409-0898","position":2,"is_corresponding":false},{"id":1141652,"name":"Haejin Lovelace","orcid":null,"position":3,"is_corresponding":false},{"id":950377,"name":"Steve Maczuga","orcid":"0000-0003-3563-6618","position":4,"is_corresponding":false},{"id":791012,"name":"Matthew F. Helm","orcid":"0000-0001-7469-8569","position":5,"is_corresponding":false},{"id":292940,"name":"Nancy J. Olsen","orcid":"0000-0002-6588-3364","position":6,"is_corresponding":false},{"id":331494,"name":"Amanda E. Nelson","orcid":"0000-0002-9344-7877","position":7,"is_corresponding":false},{"id":1122565,"name":"Galen Foulke","orcid":"0000-0002-4390-5200","position":8,"is_corresponding":false},{"id":1122563,"name":"Astia Allenzara","orcid":"0000-0003-2212-009X","position":0,"is_corresponding":true}],"reference_count":17,"raw_metadata":null,"created_at":"2026-07-19T01:16:40.346877Z","pmid":"37743678","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}