{"doi":"10.1002/acr.25618","title":"Improvements in Health‐Related Quality of Life With Treat‐to‐Target Urate‐Lowering Therapy in Gout: A Post Hoc Analysis of a Randomized Multicenter Trial","abstract":"OBJECTIVE: Although treat-to-target urate-lowering therapy (ULT) is endorsed as best practice in gout management, limited data exist on its impact on health-related quality of life (HRQoL). We assessed the impact of treat-to-target ULT on HRQoL among participants receiving protocolized gout care, identifying factors associated with HRQoL and HRQoL change. METHODS: This was a post hoc analysis of a 72-week randomized trial, pooling data from allopurinol and febuxostat treatment arms. The Veterans RAND-12 Item Health Survey and EuroQol 5-Dimension 3-Level (EQ-5D-3L) were administered at baseline and at 24, 48, and 72 weeks. HRQoL changes over follow-up were examined using paired t-tests. Factors associated with baseline HRQoL were evaluated using multivariable linear regression. General estimating equations were used to identify determinants of HRQoL change over follow-up. RESULTS: Participants (N = 878) in this analysis were 98.9% male, had a mean age of 62.4 years, and 67.4% self-reported White race. HRQoL scores overall, and particularly the domains of physical function, mobility and pain, improved significantly over 72 weeks (P < 0.001) with improvements noted by 24 weeks. Poorer enrollment HRQoL was associated with younger age, non-White race, tophi (for EQ-5D-3L), higher serum urate level, and greater comorbidity. Baseline factors associated with HRQoL improvements over 72 weeks of ULT included lower C-reactive protein level and lower comorbidity scores with similar changes observed by ULT assignment. CONCLUSION: Treat-to-target ULT in gout is accompanied by HRQoL improvements evident by 24 weeks and sustained through 72 weeks. HRQoL gains with treat-to-target ULT are most prominent in the domains of physical function, mobility, and pain and are greatest in those with lower baseline levels of inflammation and comorbidity.","journal":"Arthritis Care & Research","year":2025,"id":526472,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9624,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":314415,"name":"Bryant R. England","orcid":"0000-0002-9649-3588","position":1,"is_corresponding":false},{"id":295522,"name":"Harlan Sayles","orcid":"0000-0002-4082-8289","position":2,"is_corresponding":false},{"id":849617,"name":"Lindsay N. Helget","orcid":"0000-0001-7716-209X","position":3,"is_corresponding":false},{"id":1064229,"name":"Maria Androsenko","orcid":null,"position":4,"is_corresponding":false},{"id":850339,"name":"Hongsheng Wu","orcid":null,"position":5,"is_corresponding":false},{"id":27525,"name":"Kaleb Michaud","orcid":"0000-0002-5350-3934","position":6,"is_corresponding":false},{"id":1064230,"name":"Bridget Kramer","orcid":null,"position":7,"is_corresponding":false},{"id":850340,"name":"Jeff A. Newcomb","orcid":null,"position":8,"is_corresponding":false},{"id":11348,"name":"Mary T. Brophy","orcid":"0000-0003-2314-4368","position":9,"is_corresponding":false},{"id":849615,"name":"Anne Davis‐Karim","orcid":"0000-0002-2801-3909","position":10,"is_corresponding":false},{"id":849616,"name":"Ryan Ferguson","orcid":"0000-0001-8695-5024","position":11,"is_corresponding":false},{"id":228055,"name":"Michael H. Pillinger","orcid":"0000-0003-3168-1542","position":12,"is_corresponding":false},{"id":55625,"name":"Tuhina Neogi","orcid":"0000-0002-9515-1711","position":13,"is_corresponding":false},{"id":108987,"name":"Paul M. Palevsky","orcid":"0000-0002-7334-5400","position":14,"is_corresponding":false},{"id":343503,"name":"James R. O’Dell","orcid":null,"position":15,"is_corresponding":false},{"id":314417,"name":"Ted R. Mikuls","orcid":"0000-0002-0897-2272","position":16,"is_corresponding":false},{"id":1248748,"name":"Austin Barry","orcid":"0000-0002-2353-8378","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-19T02:50:30.402772Z","pmid":"40771143","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}